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Pdcl3 phosducin-like 3 [ Mus musculus (house mouse) ]

Gene ID: 68833, updated on 5-Mar-2024

Summary

Official Symbol
Pdcl3provided by MGI
Official Full Name
phosducin-like 3provided by MGI
Primary source
MGI:MGI:1916083
See related
Ensembl:ENSMUSG00000026078 AllianceGenome:MGI:1916083
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Viaf1; 1110061A19Rik
Summary
Enables vascular endothelial growth factor receptor 2 binding activity. Involved in angiogenesis and positive regulation of gene expression. Located in cytoplasm. Part of protein-containing complex. Orthologous to human PDCL3 (phosducin like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 53.0), CNS E11.5 (RPKM 29.5) and 26 other tissues See more
Orthologs
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Genomic context

See Pdcl3 in Genome Data Viewer
Location:
1 B; 1 17.36 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (39026895..39036317)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (38987814..38997236)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene neuromedin S Neighboring gene STARR-positive B cell enhancer ABC_E4310 Neighboring gene predicted gene, 35171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39067427-39067536 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39082036-39082298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39082340-39082541 Neighboring gene predicted gene, 35222 Neighboring gene STARR-seq mESC enhancer starr_00703 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39148051-39148289 Neighboring gene STARR-seq mESC enhancer starr_00706 Neighboring gene STARR-seq mESC enhancer starr_00707 Neighboring gene microRNA 6349

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables vascular endothelial growth factor receptor 2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinucleolar compartment ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phosducin-like protein 3
Names
IAP-associated factor VIAF1
VIAF-1
viral IAP-associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026850.4NP_081126.2  phosducin-like protein 3

    See identical proteins and their annotated locations for NP_081126.2

    Status: PROVISIONAL

    Source sequence(s)
    AC140367
    Consensus CDS
    CCDS14903.1
    UniProtKB/Swiss-Prot
    Q3TH06, Q8BVF2, Q99JX2, Q9D0W3
    Related
    ENSMUSP00000027247.6, ENSMUST00000027247.11
    Conserved Domains (1) summary
    cd02988
    Location:8203
    Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    39026895..39036317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)