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PDCL3 phosducin like 3 [ Homo sapiens (human) ]

Gene ID: 79031, updated on 1-Jun-2020

Summary

Official Symbol
PDCL3provided by HGNC
Official Full Name
phosducin like 3provided by HGNC
Primary source
HGNC:HGNC:28860
See related
Ensembl:ENSG00000115539 MIM:611678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VIAF; PHLP3; VIAF1; HTPHLP; PHLP2A
Summary
This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 9.1), esophagus (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See PDCL3 in Genome Data Viewer
Location:
2q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (100562993..100577472)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101179418..101193201)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373506 Neighboring gene neuromedin S Neighboring gene ARPP19 pseudogene 2 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 22 Neighboring gene long intergenic non-protein coding RNA 1849

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3062

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding involved in protein folding IPI
Inferred from Physical Interaction
more info
PubMed 
vascular endothelial growth factor receptor 2 binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
chaperone-mediated protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of chaperone-mediated protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinucleolar compartment IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosducin-like protein 3
Names
IAP-associated factor VIAF1
VIAF-1
phPL3
viral IAP-associated factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024065.5NP_076970.1  phosducin-like protein 3

    See identical proteins and their annotated locations for NP_076970.1

    Status: VALIDATED

    Source sequence(s)
    AI741007, BC001021
    Consensus CDS
    CCDS33261.1
    UniProtKB/Swiss-Prot
    Q9H2J4
    Related
    ENSP00000264254.6, ENST00000264254.11
    Conserved Domains (1) summary
    cd02988
    Location:8202
    Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    100562993..100577472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004890.1XP_016860379.1  phosducin-like protein 3 isoform X1

    Conserved Domains (1) summary
    cd02988
    Location:15152
    Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...
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