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TAF6 TATA-box binding protein associated factor 6 [ Homo sapiens (human) ]

Gene ID: 6878, updated on 3-Nov-2019

Summary

Official Symbol
TAF6provided by HGNC
Official Full Name
TATA-box binding protein associated factor 6provided by HGNC
Primary source
HGNC:HGNC:11540
See related
Ensembl:ENSG00000106290 MIM:602955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALYUS; TAF2E; TAFII70; TAFII80; TAFII85; MGC:8964; TAFII-70; TAFII-80; TAF(II)70; TAF(II)80
Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in testis (RPKM 19.4), endometrium (RPKM 14.3) and 25 other tissues See more
Orthologs

Genomic context

See TAF6 in Genome Data Viewer
Location:
7q22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100107070..100127208, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99704693..99717481, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene microRNA 106b Neighboring gene minichromosome maintenance complex component 7 Neighboring gene microRNA 93 Neighboring gene adaptor related protein complex 4 subunit mu 1 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene metallo-beta-lactamase domain containing 1 Neighboring gene ribosomal protein L7 pseudogene 60 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene microtubule associated protein 11 Neighboring gene microRNA 4658

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
tat TFIID subunit TAF6 binds to the TATA box and adjacent sequences (including E-box) of HIV-1 LTR, which contains nucleotides from -33 to -16 with respect to the transcriptional start site PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781E21155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
aryl hydrocarbon receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA-templated transcription, initiation IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
SAGA complex IEA
Inferred from Electronic Annotation
more info
 
SLIK (SAGA-like) complex IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 6
Names
RNA polymerase II TBP-associated factor subunit E
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD
transcription initiation factor TFIID 70 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029454.1 RefSeqGene

    Range
    5001..17789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190415.2NP_001177344.1  transcription initiation factor TFIID subunit 6 isoform epsilon

    See identical proteins and their annotated locations for NP_001177344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (epsilon) has a distinct N-terminus and is longer than isoform alpha.
    Source sequence(s)
    AK300005, CX782724, DC339989
    Consensus CDS
    CCDS55135.1
    UniProtKB/Swiss-Prot
    P49848
    Related
    ENSP00000399982.2, ENST00000437822.6
    Conserved Domains (1) summary
    cd08050
    Location:52425
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  2. NM_001364998.1NP_001351927.1  transcription initiation factor TFIID subunit 6 isoform alpha

    Status: REVIEWED

    Source sequence(s)
    AC073842
    Conserved Domains (1) summary
    cd08050
    Location:15388
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  3. NM_001364999.1NP_001351928.1  transcription initiation factor TFIID subunit 6 isoform alpha

    Status: REVIEWED

    Source sequence(s)
    AC073842
    Conserved Domains (1) summary
    cd08050
    Location:15388
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  4. NM_001365000.1NP_001351929.1  transcription initiation factor TFIID subunit 6 isoform delta

    Status: REVIEWED

    Source sequence(s)
    AC073842
    Conserved Domains (1) summary
    cd08050
    Location:15378
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  5. NM_001365001.1NP_001351930.1  transcription initiation factor TFIID subunit 6 isoform delta

    Status: REVIEWED

    Source sequence(s)
    AC073842
    Conserved Domains (1) summary
    cd08050
    Location:15378
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  6. NM_001365002.1NP_001351931.1  transcription initiation factor TFIID subunit 6 isoform delta

    Status: REVIEWED

    Source sequence(s)
    AC073842
    Conserved Domains (1) summary
    cd08050
    Location:15378
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  7. NM_001365003.1NP_001351932.1  transcription initiation factor TFIID subunit 6 isoform delta

    Status: REVIEWED

    Source sequence(s)
    AC073842
    Conserved Domains (1) summary
    cd08050
    Location:15378
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  8. NM_001365004.1NP_001351933.1  transcription initiation factor TFIID subunit 6 isoform zeta

    Status: REVIEWED

    Source sequence(s)
    AC073842
    Conserved Domains (1) summary
    cd08050
    Location:61434
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  9. NM_005641.4NP_005632.1  transcription initiation factor TFIID subunit 6 isoform alpha

    See identical proteins and their annotated locations for NP_005632.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform alpha. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    CX782724, DA707589, L25444
    Consensus CDS
    CCDS5686.1
    UniProtKB/Swiss-Prot
    P49848
    Related
    ENSP00000344537.4, ENST00000344095.8
    Conserved Domains (1) summary
    cd08050
    Location:15388
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  10. NM_139315.3NP_647476.1  transcription initiation factor TFIID subunit 6 isoform alpha

    See identical proteins and their annotated locations for NP_647476.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (alpha).
    Source sequence(s)
    BC018115, CX782724, DA150478, DA776355
    Consensus CDS
    CCDS5686.1
    UniProtKB/Swiss-Prot
    P49848
    Related
    ENSP00000389575.2, ENST00000453269.7
    Conserved Domains (1) summary
    cd08050
    Location:15388
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RNA

  1. NR_033792.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has a different 5'-most exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to inhibit the translation of the downstream primary ORF, as found in variant 1.
    Source sequence(s)
    AC073842, BC018115, CX782724, DA707589
    Related
    ENST00000421980.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100107070..100127208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446896.1XP_024302664.1  transcription initiation factor TFIID subunit 6 isoform X1

    Related
    ENSP00000419760.1, ENST00000472509.5
    Conserved Domains (1) summary
    cd08050
    Location:15388
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  2. XM_024446899.1XP_024302667.1  transcription initiation factor TFIID subunit 6 isoform X3

    Conserved Domains (1) summary
    cd08050
    Location:64437
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  3. XM_024446900.1XP_024302668.1  transcription initiation factor TFIID subunit 6 isoform X1

    Conserved Domains (1) summary
    cd08050
    Location:15388
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  4. XM_011516543.3XP_011514845.1  transcription initiation factor TFIID subunit 6 isoform X4

    See identical proteins and their annotated locations for XP_011514845.1

    UniProtKB/TrEMBL
    A4D299
    Conserved Domains (1) summary
    cd08050
    Location:15378
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_139122.1: Suppressed sequence

    Description
    NM_139122.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_139123.1: Suppressed sequence

    Description
    NM_139123.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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