TAF6 TATA-box binding protein associated factor 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAF6provided by HGNC
Official Full Name: TATA-box binding protein associated factor 6provided by HGNC
Primary source: HGNC:HGNC:11540
See related: Ensembl:ENSG00000106290 MIM:602955; AllianceGenome:HGNC:11540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALYUS; TAF2E; TAFII70; TAFII80; TAFII85; MGC:8964; TAFII-70; TAFII-80; TAF(II)70; TAF(II)80
Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Expression: Ubiquitous expression in testis (RPKM 19.4), endometrium (RPKM 14.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q22.1

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (100107070..100127171, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (101346916..101367060, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (99704693..99717481, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The third family with TAF6-related phenotype: Alazami-Yuan syndrome.
Title: The third family with TAF6-related phenotype: Alazami-Yuan syndrome.
BIM and NOXA contribute to TAF6delta-dependent cell death.
Title: BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis.
data point to several new RNA elements that can modulate TAF6delta and also reveal a role for RNA secondary structure in the selection of TAF6delta
Title: Alternative splicing of TAF6: downstream transcriptome impacts and upstream RNA splice control elements.
TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.
Title: TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.
The transcriptome data uncovered novel links between TAF6delta expression and the Notch, oxidative stress response, integrin, p53, p53 feedback loop 2, and angiogenesis pathways.
Title: TAF6delta orchestrates an apoptotic transcriptome profile and interacts functionally with p53.
TAF6delta has a pivotal node in a signaling pathway that controls gene expression programs and apoptosis in the absence of p53
Title: TAF6delta controls apoptosis and gene expression in the absence of p53.
a novel protein-protein interaction was observed between TAFII70 (not TAFII80) and GADD45a
Title: TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein.
histone fold domain mediated interaction enhances the DNA binding activity of each of the TAF6-TAF9 and TAF4b-TAF12 pairs and of a histone-like octamer complex composed of the four TAFs
Title: Core promoter binding by histone-like TAF complexes.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Alazami-Yuan syndrome MedGen: C4310702 OMIM: 617126 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro	PubMed
	tat	HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter	PubMed
	tat	TFIID subunit TAF6 binds to the TATA box and adjacent sequences (including E-box) of HIV-1 LTR, which contains nucleotides from -33 to -16 with respect to the transcriptional start site	PubMed
	tat	TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function	PubMed
	tat	Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47	PubMed
	tat	A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68321 (e-PCR)
- UniSTS:41030

STS-F01487 (e-PCR)
- UniSTS:78958

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II general transcription initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II general transcription initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables aryl hydrocarbon receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase II preinitiation complex assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in RNA polymerase II preinitiation complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of MLL1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	IEA Inferred from Electronic Annotation more info
part_of SLIK (SAGA-like) complex	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	EXP Inferred from Experiment more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIID complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription factor TFIID complex	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription factor TFTC complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFTC complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: transcription initiation factor TFIID subunit 6

Names: RNA polymerase II TBP-associated factor subunit E; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD; transcription initiation factor TFIID 70 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029454.2 RefSeqGene

Range

12813..25101

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001190415.2 → NP_001177344.1 transcription initiation factor TFIID subunit 6 isoform epsilon

See identical proteins and their annotated locations for NP_001177344.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (epsilon) has a distinct N-terminus and is longer than isoform alpha.

Source sequence(s)

AK300005, CX782724, DC339989

Consensus CDS

CCDS55135.1

UniProtKB/TrEMBL

J3KR72

Related

ENSP00000399982.2, ENST00000437822.6

Conserved Domains (1) summary

cd08050
Location:52 → 425

TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
NM_001364998.1 → NP_001351927.1 transcription initiation factor TFIID subunit 6 isoform alpha

Status: REVIEWED

Source sequence(s)

AC073842

Consensus CDS

CCDS5686.1

UniProtKB/Swiss-Prot

A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29

UniProtKB/TrEMBL

A0A8I5KRU1

Related

ENSP00000509041.1, ENST00000692466.1

Conserved Domains (2) summary

COG5095
Location:9 → 408

TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]

cd08050
Location:214 → 430

TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
NM_001364999.1 → NP_001351928.1 transcription initiation factor TFIID subunit 6 isoform alpha

Status: REVIEWED

Source sequence(s)

AC073842

Consensus CDS

CCDS5686.1

UniProtKB/Swiss-Prot

A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29

UniProtKB/TrEMBL

A0A8I5KRU1

Related

ENSP00000509335.1, ENST00000692927.1

Conserved Domains (2) summary

COG5095
Location:9 → 408

TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]

cd08050
Location:214 → 430

TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
NM_001365000.1 → NP_001351929.1 transcription initiation factor TFIID subunit 6 isoform delta

Status: REVIEWED

Source sequence(s)

AC073842

Consensus CDS

CCDS94153.1

UniProtKB/TrEMBL

A0A8I5KRU1, A4D299

Related

ENSP00000508788.1, ENST00000692408.1

Conserved Domains (1) summary

cd08050
Location:15 → 378

TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
NM_001365001.1 → NP_001351930.1 transcription initiation factor TFIID subunit 6 isoform delta

Status: REVIEWED

Source sequence(s)

AC073842

Consensus CDS

CCDS94153.1

UniProtKB/TrEMBL

A0A8I5KRU1, A4D299

Related

ENSP00000509320.1, ENST00000691010.1

Conserved Domains (1) summary

cd08050
Location:15 → 378

TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
NM_001365002.1 → NP_001351931.1 transcription initiation factor TFIID subunit 6 isoform delta

Status: REVIEWED

Source sequence(s)

AC073842

Consensus CDS

CCDS94153.1

UniProtKB/TrEMBL

A0A8I5KRU1, A4D299

Related

ENSP00000509741.1, ENST00000687672.1

Conserved Domains (1) summary

cd08050
Location:15 → 378

TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
NM_001365003.1 → NP_001351932.1 transcription initiation factor TFIID subunit 6 isoform delta

Status: REVIEWED

Source sequence(s)

AC073842

Consensus CDS

CCDS94153.1

UniProtKB/TrEMBL

A0A8I5KRU1, A4D299

Related

ENSP00000509821.1, ENST00000690367.1

Conserved Domains (1) summary

cd08050
Location:15 → 378

TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
NM_001365004.1 → NP_001351933.1 transcription initiation factor TFIID subunit 6 isoform zeta

Status: REVIEWED

Source sequence(s)

AC073842

UniProtKB/TrEMBL

A0A8I5KRU1

Conserved Domains (1) summary

cd08050
Location:61 → 434

TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
NM_005641.4 → NP_005632.1 transcription initiation factor TFIID subunit 6 isoform alpha

See identical proteins and their annotated locations for NP_005632.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform alpha. Both variants 1 and 2 encode the same isoform.

Source sequence(s)

CX782724, DA707589, L25444

Consensus CDS

CCDS5686.1

UniProtKB/Swiss-Prot

A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29

UniProtKB/TrEMBL

A0A8I5KRU1

Related

ENSP00000344537.4, ENST00000344095.8

Conserved Domains (2) summary

COG5095
Location:9 → 408

TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]

cd08050
Location:214 → 430

TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
NM_139315.3 → NP_647476.1 transcription initiation factor TFIID subunit 6 isoform alpha

See identical proteins and their annotated locations for NP_647476.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (alpha).

Source sequence(s)

BC018115, CX782724, DA150478, DA776355

Consensus CDS

CCDS5686.1

UniProtKB/Swiss-Prot

A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29

UniProtKB/TrEMBL

A0A8I5KRU1

Related

ENSP00000389575.2, ENST00000453269.7

Conserved Domains (2) summary

COG5095
Location:9 → 408

TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]

cd08050
Location:214 → 430

TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

RNA

NR_033792.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) has a different 5'-most exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to inhibit the translation of the downstream primary ORF, as found in variant 1.

Source sequence(s)

AC073842, BC018115, CX782724, DA707589

Related

ENST00000684938.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

100107070..100127171 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047420781.1 → XP_047276737.1 transcription initiation factor TFIID subunit 6 isoform X2

UniProtKB/TrEMBL

A4D299
XM_024446896.2 → XP_024302664.1 transcription initiation factor TFIID subunit 6 isoform X1

UniProtKB/Swiss-Prot

A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29

UniProtKB/TrEMBL

A0A8I5KRU1

Related

ENSP00000508432.1, ENST00000687137.1

Conserved Domains (2) summary

COG5095
Location:9 → 408

TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]

cd08050
Location:214 → 430

TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
XM_047420780.1 → XP_047276736.1 transcription initiation factor TFIID subunit 6 isoform X2

UniProtKB/TrEMBL

A4D299
XM_047420779.1 → XP_047276735.1 transcription initiation factor TFIID subunit 6 isoform X1

UniProtKB/Swiss-Prot

A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
XM_024446899.2 → XP_024302667.1 transcription initiation factor TFIID subunit 6 isoform X3

UniProtKB/TrEMBL

J3KR72

Conserved Domains (1) summary

cd08050
Location:64 → 437

TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
XM_011516543.4 → XP_011514845.1 transcription initiation factor TFIID subunit 6 isoform X2

See identical proteins and their annotated locations for XP_011514845.1

UniProtKB/TrEMBL

A0A8I5KRU1, A4D299

Conserved Domains (1) summary

cd08050
Location:15 → 378

TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
XM_024446900.2 → XP_024302668.1 transcription initiation factor TFIID subunit 6 isoform X1

UniProtKB/Swiss-Prot

A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29

UniProtKB/TrEMBL

A0A8I5KRU1

Conserved Domains (2) summary

COG5095
Location:9 → 408

TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]

cd08050
Location:214 → 430

TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

101346916..101367060 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358900.1 → XP_054214875.1 transcription initiation factor TFIID subunit 6 isoform X1

UniProtKB/Swiss-Prot

A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
XM_054358898.1 → XP_054214873.1 transcription initiation factor TFIID subunit 6 isoform X1

UniProtKB/Swiss-Prot

A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
XM_054358899.1 → XP_054214874.1 transcription initiation factor TFIID subunit 6 isoform X2

UniProtKB/TrEMBL

A4D299
XM_054358901.1 → XP_054214876.1 transcription initiation factor TFIID subunit 6 isoform X2

UniProtKB/TrEMBL

A4D299
XM_054358902.1 → XP_054214877.1 transcription initiation factor TFIID subunit 6 isoform X3
XM_054358904.1 → XP_054214879.1 transcription initiation factor TFIID subunit 6 isoform X2

UniProtKB/TrEMBL

A4D299
XM_054358903.1 → XP_054214878.1 transcription initiation factor TFIID subunit 6 isoform X1

UniProtKB/Swiss-Prot

A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_139122.1: Suppressed sequence

Description

NM_139122.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_139123.1: Suppressed sequence

Description

NM_139123.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.