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Tyw5 tRNA-yW synthesizing protein 5 [ Mus musculus (house mouse) ]

Gene ID: 68736, updated on 2-Nov-2024

Summary

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Official Symbol
Tyw5provided by MGI
Official Full Name
tRNA-yW synthesizing protein 5provided by MGI
Primary source
MGI:MGI:1915986
See related
Ensembl:ENSMUSG00000048495 AllianceGenome:MGI:1915986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110034B05Rik
Summary
Predicted to enable several functions, including iron ion binding activity; protein homodimerization activity; and tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity. Predicted to be involved in wybutosine biosynthetic process. Orthologous to human TYW5 (tRNA-yW synthesizing protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 4.4), placenta adult (RPKM 4.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Tyw5 in Genome Data Viewer
Location:
1 C1.3; 1 28.78 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (57427394..57445833, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (57388235..57406674, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930558J18 gene Neighboring gene RIKEN cDNA 1700066M21 gene Neighboring gene STARR-seq mESC enhancer starr_00984 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:57463249-57463358 Neighboring gene matrix AAA peptidase interacting protein 1 Neighboring gene predicted gene, 22371 Neighboring gene predicted gene, 53555 Neighboring gene STARR-seq mESC enhancer starr_00987

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. Kato M, et al. Nucleic Acids Res, 2011 Mar. PMID 20972222, Free PMC Article
  2. The genetic program of hematopoietic stem cells. Phillips RL, et al. Science, 2000 Jun 2. PMID 10834841
  3. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • FLJ37953, MGC117744

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in wybutosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wybutosine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in wybutosine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
tRNA wybutosine-synthesizing protein 5
Names
jmjC domain-containing protein C2orf60 homolog
tRNA yW-synthesizing enzyme 5
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase
NP_001032831.2
NP_001289891.1
NP_001289892.1
NP_001289893.1
XP_011236889.1
XP_017177819.1
XP_036009262.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037742.2 → NP_001032831.2  tRNA wybutosine-synthesizing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001032831.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region, compared to variant 4. The resulting protein (isoform 1) is shorter than isoform 4.
    Source sequence(s)
    AC161493, BC099495, BC132289, BU697704
    Consensus CDS
    CCDS14966.2
    UniProtKB/Swiss-Prot
    A2RSX7, Q3UT82, Q4KL17
    Related
    ENSMUSP00000125427.2, ENSMUST00000162686.8
    Conserved Domains (1) summary
    pfam13621
    Location:17 → 255
    Cupin_8; Cupin-like domain

  2. NM_001302962.1 → NP_001289891.1  tRNA wybutosine-synthesizing protein 5 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC161493, BC099495, BC144765, BU697704, CF951173
    UniProtKB/TrEMBL
    G3UW53
    Related
    ENSMUSP00000128576.2, ENSMUST00000160837.8
    Conserved Domains (1) summary
    pfam13621
    Location:17 → 257
    Cupin_8; Cupin-like domain

  3. NM_001302963.1 → NP_001289892.1  tRNA wybutosine-synthesizing protein 5 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon, uses an alternate in-frame splice site in the 5' coding region, and uses an in-frame downstream start codon compared to variant 4. The resulting protein (isoform 5) is shorter than isoform 4.
    Source sequence(s)
    AC161493, BC099495, BC144765
    Conserved Domains (1) summary
    cl21464
    Location:13 → 115
    cupin_like; Conserved domain found in cupin and related proteins

  4. NM_001302964.1 → NP_001289893.1  tRNA wybutosine-synthesizing protein 5 isoform 3

    See identical proteins and their annotated locations for NP_001289893.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon and uses an in-frame downstream start codon compared to variant 4. The resulting protein (isoform 3) has a shorter N-terminus than isoform 4.
    Source sequence(s)
    AC161493, BC099495, BC144766
    Conserved Domains (1) summary
    pfam13621
    Location:13 → 120
    Cupin_8; Cupin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    57427394..57445833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322330.1 → XP_017177819.1  tRNA wybutosine-synthesizing protein 5 isoform X2

    Conserved Domains (1) summary
    pfam13621
    Location:26 → 162
    Cupin_8; Cupin-like domain

  2. XM_011238587.2 → XP_011236889.1  tRNA wybutosine-synthesizing protein 5 isoform X3

    See identical proteins and their annotated locations for XP_011236889.1

    Conserved Domains (1) summary
    pfam13621
    Location:13 → 120
    Cupin_8; Cupin-like domain

  3. XM_036153369.1 → XP_036009262.1  tRNA wybutosine-synthesizing protein 5 isoform X1

    Conserved Domains (1) summary
    pfam13621
    Location:37 → 183
    Cupin_8; Cupin-like domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001114102.1: Suppressed sequence

    Description
    NM_001114102.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RSX7.2 GenPept UniProtKB/Swiss-Prot:A2RSX7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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