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TYW5 tRNA-yW synthesizing protein 5 [ Homo sapiens (human) ]

Gene ID: 129450, updated on 24-Nov-2020

Summary

Official Symbol
TYW5provided by HGNC
Official Full Name
tRNA-yW synthesizing protein 5provided by HGNC
Primary source
HGNC:HGNC:26754
See related
Ensembl:ENSG00000162971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hTYW5; C2orf60
Expression
Ubiquitous expression in bone marrow (RPKM 2.6), thyroid (RPKM 2.0) and 25 other tissues See more
Orthologs

Genomic context

See TYW5 in Genome Data Viewer
Location:
2q33.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (199928913..199955624, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (200793634..200820459, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927687 Neighboring gene RNA, 7SL, cytoplasmic 717, pseudogene Neighboring gene chromosome 2 open reading frame 69 Neighboring gene matrix AAA peptidase interacting protein 1 Neighboring gene uncharacterized LOC105373833 Neighboring gene spermatogenesis associated serine rich 2 like Neighboring gene RNY4 pseudogene 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37953, MGC70509

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2-oxoglutarate-dependent dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
2-oxoglutarate-dependent dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
tRNA modification TAS
Traceable Author Statement
more info
 
wybutosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
wybutosine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tRNA wybutosine-synthesizing protein 5
Names
jmjC domain-containing protein C2orf60
tRNA yW-synthesizing enzyme 5
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase
NP_001034782.1
XP_016858799.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039693.3NP_001034782.1  tRNA wybutosine-synthesizing protein 5

    See identical proteins and their annotated locations for NP_001034782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and is the protein-coding transcript.
    Source sequence(s)
    AC097717, BC132835, BM673915
    Consensus CDS
    CCDS42795.1
    UniProtKB/Swiss-Prot
    A2RUC4
    Related
    ENSP00000346627.4, ENST00000354611.9
    Conserved Domains (1) summary
    pfam13621
    Location:17255
    Cupin_8; Cupin-like domain

RNA

  1. NR_004862.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the second exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC097717, BC025758, BM673915, BX647677
  2. NR_109905.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC097717, AK095272, BM673915, HY182974
  3. NR_109906.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the second exon and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC097717, AK293064, BM673915
  4. NR_109907.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC097717, AK095272, BM673915

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    199928913..199955624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003310.2XP_016858799.1  tRNA wybutosine-synthesizing protein 5 isoform X1

RNA

  1. XR_001738610.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152382.1: Suppressed sequence

    Description
    NM_152382.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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