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Carmil1 capping protein regulator and myosin 1 linker 1 [ Mus musculus (house mouse) ]

Gene ID: 68732, updated on 5-Mar-2024

Summary

Official Symbol
Carmil1provided by MGI
Official Full Name
capping protein regulator and myosin 1 linker 1provided by MGI
Primary source
MGI:MGI:1915982
See related
Ensembl:ENSMUSG00000021338 AllianceGenome:MGI:1915982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CARMIL; CARML1; Lrrc16; Lrrc16a; D130057M20; 1110037D04Rik
Summary
Involved in several processes, including positive regulation of lamellipodium organization; positive regulation of substrate adhesion-dependent cell spreading; and positive regulation of supramolecular fiber organization. Located in lamellipodium. Part of filamentous actin. Is expressed in palatal shelf; skeleton; telencephalon; and vibrissa. Orthologous to human CARMIL1 (capping protein regulator and myosin 1 linker 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 3.6), CNS E18 (RPKM 3.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
13 A3.1; 13 10.05 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (24196464..24464983, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (24012481..24280802, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33516 Neighboring gene H2A clustered histone 1 Neighboring gene STARR-seq mESC enhancer starr_33976 Neighboring gene secretagogin, EF-hand calcium binding protein Neighboring gene STARR-seq mESC enhancer starr_33977 Neighboring gene STARR-seq mESC enhancer starr_33978 Neighboring gene STARR-seq mESC enhancer starr_33979 Neighboring gene predicted gene, 33573 Neighboring gene STARR-seq mESC enhancer starr_33980 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 23340 Neighboring gene ribosomal protein L27a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-containing complex binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament network formation ISO
Inferred from Sequence Orthology
more info
 
involved_in barbed-end actin filament uncapping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in macropinocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of barbed-end actin filament capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lamellipodium organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lamellipodium organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ruffle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of filamentous actin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in macropinosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
F-actin-uncapping protein LRRC16A
Names
CARMIL homolog
capping protein regulator and myosin 1 linker protein 1
capping protein, Arp2/3 and myosin-I linker homolog 1
capping protein, Arp2/3 and myosin-I linker protein 1
leucine rich repeat containing 16
leucine rich repeat containing 16A
leucine-rich repeat-containing protein 16A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311122.1NP_001298051.1  F-actin-uncapping protein LRRC16A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region and contains an alternate 3' exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL590864, AL606464, AL683873
    Consensus CDS
    CCDS79171.1
    UniProtKB/TrEMBL
    D3Z030
    Related
    ENSMUSP00000106028.3, ENSMUST00000110398.8
    Conserved Domains (5) summary
    PHA02682
    Location:11091314
    PHA02682; ORF080 virion core protein; Provisional
    COG4886
    Location:312581
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:281595
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7861076
    CARMIL_C; CARMIL C-terminus
  2. NM_001384122.1NP_001371051.1  F-actin-uncapping protein LRRC16A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL590864, AL606464, AL683873
    Conserved Domains (5) summary
    PHA02682
    Location:11091314
    PHA02682; ORF080 virion core protein; Provisional
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7861076
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:281595
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  3. NM_026825.3NP_081101.3  F-actin-uncapping protein LRRC16A isoform 1

    See identical proteins and their annotated locations for NP_081101.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK004138, AK043591, AK051570, AY437876
    Consensus CDS
    CCDS36621.1
    UniProtKB/Swiss-Prot
    Q5NCM0, Q6EDY6, Q8BQ45, Q8BRS5, Q91YZ6
    Related
    ENSMUSP00000072662.6, ENSMUST00000072889.12
    Conserved Domains (6) summary
    PHA02682
    Location:11131318
    PHA02682; ORF080 virion core protein; Provisional
    COG4886
    Location:312585
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:229373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:248275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7901080
    CARMIL_C; CARMIL C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    24196464..24464983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315585.3XP_017171074.1  F-actin-uncapping protein LRRC16A isoform X7

    Conserved Domains (5) summary
    PHA03307
    Location:9971384
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7861075
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:281595
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. XM_011244335.4XP_011242637.1  F-actin-uncapping protein LRRC16A isoform X3

    Conserved Domains (5) summary
    PHA02682
    Location:11151320
    PHA02682; ORF080 virion core protein; Provisional
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7861081
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:281595
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  3. XM_017315584.3XP_017171073.1  F-actin-uncapping protein LRRC16A isoform X5

    Conserved Domains (6) summary
    PHA03307
    Location:10011388
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00031
    Location:248275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7901079
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:229373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  4. XM_017315586.3XP_017171075.1  F-actin-uncapping protein LRRC16A isoform X11

    Conserved Domains (6) summary
    PHA02682
    Location:11131318
    PHA02682; ORF080 virion core protein; Provisional
    sd00031
    Location:248275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7901079
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:229373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  5. XM_011244340.4XP_011242642.1  F-actin-uncapping protein LRRC16A isoform X12

    Conserved Domains (6) summary
    PHA03307
    Location:10071323
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00031
    Location:248275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7901085
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:229373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  6. XM_011244336.4XP_011242638.1  F-actin-uncapping protein LRRC16A isoform X8

    Conserved Domains (6) summary
    PHA02682
    Location:11191324
    PHA02682; ORF080 virion core protein; Provisional
    sd00031
    Location:248275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7901085
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:229373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  7. XM_011244334.4XP_011242636.1  F-actin-uncapping protein LRRC16A isoform X2

    Conserved Domains (6) summary
    PHA03307
    Location:10071394
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00031
    Location:248275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7901085
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:229373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  8. XM_011244333.4XP_011242635.1  F-actin-uncapping protein LRRC16A isoform X1

    Conserved Domains (6) summary
    PHA02682
    Location:11191324
    PHA02682; ORF080 virion core protein; Provisional
    sd00031
    Location:248275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7901085
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:229373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  9. XM_011244338.4XP_011242640.1  F-actin-uncapping protein LRRC16A isoform X10

    See identical proteins and their annotated locations for XP_011242640.1

    UniProtKB/Swiss-Prot
    Q6EDY6
    Conserved Domains (6) summary
    PHA02682
    Location:11191324
    PHA02682; ORF080 virion core protein; Provisional
    sd00031
    Location:248275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7901085
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:229373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  10. XM_036158147.1XP_036014040.1  F-actin-uncapping protein LRRC16A isoform X9

    Conserved Domains (6) summary
    PHA02682
    Location:10361241
    PHA02682; ORF080 virion core protein; Provisional
    sd00031
    Location:165192
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:224255
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7071003
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:136
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:146290
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  11. XM_011244337.4XP_011242639.1  F-actin-uncapping protein LRRC16A isoform X9

    Conserved Domains (6) summary
    PHA02682
    Location:10361241
    PHA02682; ORF080 virion core protein; Provisional
    sd00031
    Location:165192
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:224255
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7071003
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:136
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:146290
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  12. XM_036158148.1XP_036014041.1  F-actin-uncapping protein LRRC16A isoform X14

    Conserved Domains (5) summary
    PHA03307
    Location:9971313
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7861076
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:281595
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  13. XM_006516741.4XP_006516804.1  F-actin-uncapping protein LRRC16A isoform X6

    Conserved Domains (5) summary
    PHA02682
    Location:11091314
    PHA02682; ORF080 virion core protein; Provisional
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7861075
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:281595
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  14. XM_030247393.2XP_030103253.1  F-actin-uncapping protein LRRC16A isoform X13

    Conserved Domains (6) summary
    PHA03307
    Location:10011317
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00031
    Location:248275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7901079
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:229373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  15. XM_006516739.4XP_006516802.1  F-actin-uncapping protein LRRC16A isoform X4

    Conserved Domains (6) summary
    PHA02682
    Location:11131318
    PHA02682; ORF080 virion core protein; Provisional
    sd00031
    Location:248275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:307338
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7901079
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:229373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RNA

  1. XR_001780807.3 RNA Sequence

  2. XR_001780806.3 RNA Sequence

  3. XR_001780808.3 RNA Sequence

  4. XR_001780812.3 RNA Sequence

  5. XR_004938063.1 RNA Sequence

  6. XR_001780810.3 RNA Sequence

  7. XR_001780811.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177807.2: Suppressed sequence

    Description
    NM_177807.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.