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Dus1l dihydrouridine synthase 1 like [ Mus musculus (house mouse) ]

Gene ID: 68730, updated on 6-Jun-2024

Summary

Official Symbol
Dus1lprovided by MGI
Official Full Name
dihydrouridine synthase 1 likeprovided by MGI
Primary source
MGI:MGI:1915980
See related
Ensembl:ENSMUSG00000025155 AllianceGenome:MGI:1915980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110032N12Rik
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Predicted to act upstream of or within tRNA processing. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 37.4), testis adult (RPKM 31.0) and 28 other tissues See more
Orthologs
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Genomic context

See Dus1l in Genome Data Viewer
Location:
11 E2; 11 84.54 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120678385..120687254, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120787559..120796427, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31367 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120637476-120637735 Neighboring gene NADPH-dependent carbonyl reductase pseudogene Neighboring gene STARR-seq mESC enhancer starr_31368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120657732-120657915 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene fatty acid synthase Neighboring gene STARR-positive B cell enhancer ABC_E9039 Neighboring gene coiled-coil domain containing 57 Neighboring gene STARR-seq mESC enhancer starr_31373 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120794121-120794304

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tRNA-dihydrouridine16 synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA-dihydrouridine17 synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in tRNA dihydrouridine synthesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
NP_001404854.1
NP_001404855.1
NP_001404856.1
NP_001404857.1
NP_001404858.1
NP_001404859.1
NP_081100.2
XP_011247517.1
XP_011247518.1
XP_017170221.1
XP_036012830.1
XP_036012833.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417925.1NP_001404854.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL663090
    UniProtKB/Swiss-Prot
    Q8C2P3, Q8VCN7, Q9D124
    UniProtKB/TrEMBL
    B1ATU5
    Related
    ENSMUSP00000101741.2, ENSMUST00000106135.8
  2. NM_001417926.1NP_001404855.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663090
    UniProtKB/TrEMBL
    B1ATU5
  3. NM_001417927.1NP_001404856.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL663090
    UniProtKB/Swiss-Prot
    Q8C2P3, Q8VCN7, Q9D124
    UniProtKB/TrEMBL
    B1ATU5
  4. NM_001417928.1NP_001404857.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL663090
    UniProtKB/Swiss-Prot
    Q8C2P3, Q8VCN7, Q9D124
    UniProtKB/TrEMBL
    B1ATU5
  5. NM_001417929.1NP_001404858.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663090
    UniProtKB/TrEMBL
    B1ATU5
  6. NM_001417930.1NP_001404859.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663090
  7. NM_026824.5NP_081100.2  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

    See identical proteins and their annotated locations for NP_081100.2

    Status: VALIDATED

    Source sequence(s)
    AL663090
    Consensus CDS
    CCDS49012.1
    UniProtKB/Swiss-Prot
    Q8C2P3, Q8VCN7, Q9D124
    UniProtKB/TrEMBL
    B1ATU5
    Related
    ENSMUSP00000132516.2, ENSMUST00000167023.8
    Conserved Domains (2) summary
    TIGR01623
    Location:396431
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:18250
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RNA

  1. NR_184653.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663090
  2. NR_184654.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663090
  3. NR_184655.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663090

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120678385..120687254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156937.1XP_036012830.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X4

    UniProtKB/TrEMBL
    B1ATU5
    Conserved Domains (2) summary
    TIGR01623
    Location:379414
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:18233
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
  2. XM_011249215.4XP_011247517.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X3

    UniProtKB/TrEMBL
    B1ATU5
    Conserved Domains (2) summary
    TIGR01623
    Location:395430
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:34249
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
  3. XM_036156940.1XP_036012833.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

    Conserved Domains (3) summary
    TIGR01623
    Location:212247
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cl21457
    Location:366
    TIM; TIM-like beta/alpha barrel domains
    cl40685
    Location:3132
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
  4. XM_011249216.3XP_011247518.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

    See identical proteins and their annotated locations for XP_011247518.1

    Conserved Domains (3) summary
    TIGR01623
    Location:212247
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cl21457
    Location:366
    TIM; TIM-like beta/alpha barrel domains
    cl40685
    Location:3132
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
  5. XM_017314732.3XP_017170221.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

    UniProtKB/TrEMBL
    B1ATU5
    Conserved Domains (2) summary
    TIGR01623
    Location:412447
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:34266
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...