Dus1l dihydrouridine synthase 1-like (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dus1lprovided by MGI
Official Full Name: dihydrouridine synthase 1-like (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:1915980
See related: Ensembl:ENSMUSG00000025155 AllianceGenome:MGI:1915980
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110032N12Rik
Summary: Predicted to enable tRNA dihydrouridine synthase activity. Predicted to act upstream of or within tRNA processing. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 37.4), testis adult (RPKM 31.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11; 11 E2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120680011..120687343, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120787559..120796427, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Homology

Homologs of the Dus1l gene: The Dus1l gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 491 organisms have orthologs with human gene Dus1l
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables tRNA dihydrouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables tRNA-dihydrouridine17 synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA dihydrouridine synthesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

NP_081100.2

EC 1.3.1.88

XP_006534140.1

EC 1.3.1.88

XP_011247515.1

EC 1.3.1.88

XP_011247516.1

EC 1.3.1.88

XP_011247517.1

EC 1.3.1.88

XP_011247518.1

EC 1.3.1.88

XP_011247519.1

EC 1.3.1.88

XP_017170221.1

EC 1.3.1.88

XP_036012828.1

EC 1.3.1.88

XP_036012829.1

EC 1.3.1.88

XP_036012830.1

EC 1.3.1.88

XP_036012831.1

EC 1.3.1.88

XP_036012832.1

EC 1.3.1.88

XP_036012833.1

EC 1.3.1.88

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417925.1 → NP_001404854.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

Status: VALIDATED

Source sequence(s)

AL663090
NM_001417926.1 → NP_001404855.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 2

Status: VALIDATED

Source sequence(s)

AL663090
NM_001417927.1 → NP_001404856.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

Status: VALIDATED

Source sequence(s)

AL663090
NM_001417928.1 → NP_001404857.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

Status: VALIDATED

Source sequence(s)

AL663090
NM_001417929.1 → NP_001404858.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 2

Status: VALIDATED

Source sequence(s)

AL663090
NM_001417930.1 → NP_001404859.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 3

Status: VALIDATED

Source sequence(s)

AL663090
NM_026824.5 → NP_081100.2 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

See identical proteins and their annotated locations for NP_081100.2

Status: VALIDATED

Source sequence(s)

AL663090

Consensus CDS

CCDS49012.1

UniProtKB/Swiss-Prot

Q8C2P3, Q9D124

UniProtKB/TrEMBL

A0A8C6I2W4

Related

ENSMUSP00000132516.2, ENSMUST00000167023.8

Conserved Domains (2) summary

TIGR01623
Location:396 → 431

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:18 → 250

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RNA

NR_184653.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL663090
NR_184654.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL663090
NR_184655.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL663090

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

120680011..120687343 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156937.1 → XP_036012830.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X4

Conserved Domains (2) summary

TIGR01623
Location:379 → 414

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:18 → 233

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
XM_036156936.1 → XP_036012829.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X4

Conserved Domains (2) summary

TIGR01623
Location:379 → 414

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:18 → 233

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
XM_011249215.4 → XP_011247517.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X3

Conserved Domains (2) summary

TIGR01623
Location:395 → 430

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:34 → 249

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
XM_036156935.1 → XP_036012828.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X4

Conserved Domains (2) summary

TIGR01623
Location:379 → 414

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:18 → 233

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
XM_011249217.3 → XP_011247519.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

Conserved Domains (3) summary

TIGR01623
Location:212 → 247

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cl21457
Location:3 → 66

TIM; TIM-like beta/alpha barrel domains

cl40685
Location:3 → 132

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
XM_036156940.1 → XP_036012833.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

Conserved Domains (3) summary

TIGR01623
Location:212 → 247

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cl21457
Location:3 → 66

TIM; TIM-like beta/alpha barrel domains

cl40685
Location:3 → 132

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
XM_036156938.1 → XP_036012831.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

Conserved Domains (3) summary

TIGR01623
Location:212 → 247

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cl21457
Location:3 → 66

TIM; TIM-like beta/alpha barrel domains

cl40685
Location:3 → 132

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
XM_036156939.1 → XP_036012832.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

Conserved Domains (3) summary

TIGR01623
Location:212 → 247

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cl21457
Location:3 → 66

TIM; TIM-like beta/alpha barrel domains

cl40685
Location:3 → 132

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
XM_011249216.3 → XP_011247518.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

See identical proteins and their annotated locations for XP_011247518.1

Conserved Domains (3) summary

TIGR01623
Location:212 → 247

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cl21457
Location:3 → 66

TIM; TIM-like beta/alpha barrel domains

cl40685
Location:3 → 132

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
XM_006534077.5 → XP_006534140.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X2

UniProtKB/Swiss-Prot

Q8C2P3, Q9D124

UniProtKB/TrEMBL

A0A8C6I2W4

Conserved Domains (2) summary

TIGR01623
Location:396 → 431

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:18 → 250

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
XM_011249214.4 → XP_011247516.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X2

UniProtKB/Swiss-Prot

Q8C2P3, Q9D124

UniProtKB/TrEMBL

A0A8C6I2W4

Conserved Domains (2) summary

TIGR01623
Location:396 → 431

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:18 → 250

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
XM_011249213.4 → XP_011247515.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X2

UniProtKB/Swiss-Prot

Q8C2P3, Q9D124

UniProtKB/TrEMBL

A0A8C6I2W4

Related

ENSMUSP00000101741.2, ENSMUST00000106135.8

Conserved Domains (2) summary

TIGR01623
Location:396 → 431

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:18 → 250

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
XM_017314732.3 → XP_017170221.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

Conserved Domains (2) summary

TIGR01623
Location:412 → 447

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:34 → 266

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...