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Dus1l dihydrouridine synthase 1 like [ Mus musculus (house mouse) ]

Gene ID: 68730, updated on 2-Nov-2024

Summary

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Official Symbol
Dus1lprovided by MGI
Official Full Name
dihydrouridine synthase 1 likeprovided by MGI
Primary source
MGI:MGI:1915980
See related
Ensembl:ENSMUSG00000025155 AllianceGenome:MGI:1915980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110032N12Rik
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 37.4), testis adult (RPKM 31.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dus1l in Genome Data Viewer
Location:
11 E2; 11 84.54 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120678385..120687254, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120787559..120796427, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31367 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120637476-120637735 Neighboring gene NADPH-dependent carbonyl reductase pseudogene Neighboring gene STARR-seq mESC enhancer starr_31368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120657732-120657915 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene fatty acid synthase Neighboring gene STARR-positive B cell enhancer ABC_E9039 Neighboring gene coiled-coil domain containing 57 Neighboring gene STARR-seq mESC enhancer starr_31373 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120794121-120794304

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-dihydrouridine16 synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-dihydrouridine17 synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA dihydrouridine synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA dihydrouridine synthesis ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
NP_001404854.1
NP_001404855.1
NP_001404856.1
NP_001404857.1
NP_001404858.1
NP_001404859.1
NP_081100.2
XP_011247517.1
XP_011247518.1
XP_017170221.1
XP_036012830.1
XP_036012833.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417925.1 → NP_001404854.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL663090
    UniProtKB/Swiss-Prot
    Q8C2P3, Q8VCN7, Q9D124
    Related
    ENSMUSP00000101741.2, ENSMUST00000106135.8

  2. NM_001417926.1 → NP_001404855.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663090

  3. NM_001417927.1 → NP_001404856.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL663090
    UniProtKB/Swiss-Prot
    Q8C2P3, Q8VCN7, Q9D124

  4. NM_001417928.1 → NP_001404857.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL663090
    UniProtKB/Swiss-Prot
    Q8C2P3, Q8VCN7, Q9D124

  5. NM_001417929.1 → NP_001404858.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663090

  6. NM_001417930.1 → NP_001404859.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663090

  7. NM_026824.5 → NP_081100.2  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1

    See identical proteins and their annotated locations for NP_081100.2

    Status: VALIDATED

    Source sequence(s)
    AL663090
    Consensus CDS
    CCDS49012.1
    UniProtKB/Swiss-Prot
    Q8C2P3, Q8VCN7, Q9D124
    UniProtKB/TrEMBL
    B1ATU5
    Related
    ENSMUSP00000132516.2, ENSMUST00000167023.8
    Conserved Domains (2) summary
    TIGR01623
    Location:396 → 431
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:18 → 250
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RNA

  1. NR_184653.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663090

  2. NR_184654.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663090

  3. NR_184655.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663090

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120678385..120687254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156937.1 → XP_036012830.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X4

    UniProtKB/TrEMBL
    B1ATU5
    Conserved Domains (2) summary
    TIGR01623
    Location:379 → 414
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:18 → 233
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  2. XM_011249215.4 → XP_011247517.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X3

    UniProtKB/TrEMBL
    B1ATU5
    Conserved Domains (2) summary
    TIGR01623
    Location:395 → 430
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:34 → 249
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  3. XM_036156940.1 → XP_036012833.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

    Conserved Domains (3) summary
    TIGR01623
    Location:212 → 247
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cl21457
    Location:3 → 66
    TIM; TIM-like beta/alpha barrel domains
    cl40685
    Location:3 → 132
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

  4. XM_011249216.3 → XP_011247518.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

    See identical proteins and their annotated locations for XP_011247518.1

    Conserved Domains (3) summary
    TIGR01623
    Location:212 → 247
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cl21457
    Location:3 → 66
    TIM; TIM-like beta/alpha barrel domains
    cl40685
    Location:3 → 132
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

  5. XM_017314732.3 → XP_017170221.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

    UniProtKB/TrEMBL
    B1ATU5
    Conserved Domains (2) summary
    TIGR01623
    Location:412 → 447
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:34 → 266
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C2P3.1 GenPept UniProtKB/Swiss-Prot:Q8C2P3

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