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DUS1L dihydrouridine synthase 1 like [ Homo sapiens (human) ]

Gene ID: 64118, updated on 6-Sep-2022

Summary

Official Symbol
DUS1Lprovided by HGNC
Official Full Name
dihydrouridine synthase 1 likeprovided by HGNC
Primary source
HGNC:HGNC:30086
See related
Ensembl:ENSG00000169718 AllianceGenome:HGNC:30086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUS1; PP3111
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 23.4), prostate (RPKM 22.1) and 25 other tissues See more
Orthologs
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Genomic context

See DUS1L in Genome Data Viewer
Location:
17q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82057506..82065804, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82924664..82932962, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80015382..80023680, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene DCXR divergent transcript Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene fatty acid synthase Neighboring gene small nucleolar RNA, C/D box 134 Neighboring gene coiled-coil domain containing 57 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA dihydrouridine synthesis IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
NP_071439.3
XP_005256450.1
XP_005256451.1
XP_006722351.1
XP_006722352.1
XP_024306636.1
XP_024306637.1
XP_024306638.1
XP_024306639.1
XP_047292475.1
XP_047292476.1
XP_047292477.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022156.5NP_071439.3  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

    See identical proteins and their annotated locations for NP_071439.3

    Status: VALIDATED

    Source sequence(s)
    AC135056, BC062566, BC064918, DB481578
    Consensus CDS
    CCDS32775.1
    UniProtKB/Swiss-Prot
    Q6P1R4, Q96AI3
    Related
    ENSP00000303515.5, ENST00000306796.10
    Conserved Domains (2) summary
    cd02801
    Location:18250
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cl27070
    Location:395429
    DUF702; Domain of unknown function (DUF702)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    82057506..82065804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722289.3XP_006722352.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X6

    Conserved Domains (3) summary
    TIGR01623
    Location:377412
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:18233
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:20290
    Dus; Dihydrouridine synthase (Dus)
  2. XM_006722288.3XP_006722351.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X4

    Conserved Domains (2) summary
    cd02801
    Location:18233
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:20290
    Dus; Dihydrouridine synthase (Dus)
  3. XM_024450869.2XP_024306637.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X2

    Conserved Domains (1) summary
    cd02801
    Location:18215
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
  4. XM_005256394.3XP_005256451.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X8

    Conserved Domains (2) summary
    cd02801
    Location:18250
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:20307
    Dus; Dihydrouridine synthase (Dus)
  5. XM_005256393.3XP_005256450.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X3

    Conserved Domains (2) summary
    cd02801
    Location:18250
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:20307
    Dus; Dihydrouridine synthase (Dus)
  6. XM_024450871.2XP_024306639.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X7

    Conserved Domains (1) summary
    cd02801
    Location:18232
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
  7. XM_024450870.2XP_024306638.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

    Conserved Domains (2) summary
    cd02801
    Location:18232
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cl27070
    Location:412447
    DUF702; Domain of unknown function (DUF702)
  8. XM_024450868.2XP_024306636.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

    Conserved Domains (1) summary
    cd02801
    Location:18232
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
  9. XM_047436519.1XP_047292475.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

  10. XM_047436520.1XP_047292476.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X9

  11. XM_047436521.1XP_047292477.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X9

RNA

  1. XR_002958052.2 RNA Sequence

    Related
    ENST00000582529.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82924664..82932962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)