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Trp53inp2 transformation related protein 53 inducible nuclear protein 2 [ Mus musculus (house mouse) ]

Gene ID: 68728, updated on 1-Mar-2024

Summary

Official Symbol
Trp53inp2provided by MGI
Official Full Name
transformation related protein 53 inducible nuclear protein 2provided by MGI
Primary source
MGI:MGI:1915978
See related
Ensembl:ENSMUSG00000038375 AllianceGenome:MGI:1915978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tp53inp2; 1110029F20Rik
Summary
Enables ubiquitin binding activity. Acts upstream of or within several processes, including macroautophagy; osteoblast differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in autophagosome and nucleus. Is expressed in several structures, including 1st branchial arch; facial prominence; limb mesenchyme; nervous system; and otocyst. Orthologous to human TP53INP2 (tumor protein p53 inducible nuclear protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 127.9), heart adult (RPKM 122.6) and 24 other tissues See more
Orthologs
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Genomic context

See Trp53inp2 in Genome Data Viewer
Location:
2 H1; 2 77.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155223742..155231767)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155381811..155389847)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 1 light chain 3 alpha Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class U Neighboring gene STARR-positive B cell enhancer ABC_E6004 Neighboring gene microRNA 695 Neighboring gene STARR-positive B cell enhancer ABC_E11173 Neighboring gene STARR-positive B cell enhancer ABC_E4511 Neighboring gene nuclear receptor coactivator 6 Neighboring gene ribosomal protein L8 pseudogene Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor protein p53-inducible nuclear protein 2
Names
diabetes and obesity-regulated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418655.1NP_001405584.1  tumor protein p53-inducible nuclear protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL845325
    UniProtKB/Swiss-Prot
    Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
  2. NM_001418656.1NP_001405585.1  tumor protein p53-inducible nuclear protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL845325
    UniProtKB/Swiss-Prot
    Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
  3. NM_001418657.1NP_001405586.1  tumor protein p53-inducible nuclear protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL845325
    UniProtKB/Swiss-Prot
    Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
  4. NM_001418658.1NP_001405587.1  tumor protein p53-inducible nuclear protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL845325
    UniProtKB/TrEMBL
    G3UXZ2
    Related
    ENSMUSP00000133880.2, ENSMUST00000174685.8
  5. NM_001418659.1NP_001405588.1  tumor protein p53-inducible nuclear protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL845325
    UniProtKB/TrEMBL
    G3UXZ2
  6. NM_001418660.1NP_001405589.1  tumor protein p53-inducible nuclear protein 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL845325
  7. NM_001418661.1NP_001405590.1  tumor protein p53-inducible nuclear protein 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL845325
  8. NM_178111.4NP_835212.1  tumor protein p53-inducible nuclear protein 2 isoform a

    See identical proteins and their annotated locations for NP_835212.1

    Status: VALIDATED

    Source sequence(s)
    AL845325
    Consensus CDS
    CCDS16947.1
    UniProtKB/Swiss-Prot
    Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
    Related
    ENSMUSP00000037627.8, ENSMUST00000043237.14
    Conserved Domains (1) summary
    pfam14839
    Location:28212
    DOR; DOR family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155223742..155231767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252040.2XP_030107900.1  tumor protein p53-inducible nuclear protein 2 isoform X3

    Conserved Domains (1) summary
    pfam14839
    Location:72217
    DOR; DOR family
  2. XM_017319242.2XP_017174731.1  tumor protein p53-inducible nuclear protein 2 isoform X3

    Conserved Domains (1) summary
    pfam14839
    Location:72217
    DOR; DOR family