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TP53INP2 tumor protein p53 inducible nuclear protein 2 [ Homo sapiens (human) ]

Gene ID: 58476, updated on 22-Aug-2021

Summary

Official Symbol
TP53INP2provided by HGNC
Official Full Name
tumor protein p53 inducible nuclear protein 2provided by HGNC
Primary source
HGNC:HGNC:16104
See related
Ensembl:ENSG00000078804 MIM:617549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOR; PIGU; PINH; PIG-U; C20orf110; dJ1181N3.1
Summary
The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in esophagus (RPKM 35.1), brain (RPKM 34.7) and 25 other tissues See more
Orthologs
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Genomic context

See TP53INP2 in Genome Data Viewer
Location:
20q11.22
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (34704344..34713439)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33292148..33301240)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class U Neighboring gene uncharacterized LOC105372599 Neighboring gene nuclear receptor coactivator 6 Neighboring gene high mobility group box 3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21759, FLJ23500, DKFZp434B2411, DKFZp434O0827

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tissue homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
 
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tumor protein p53-inducible nuclear protein 2
Names
diabetes and obesity-regulated
p53-inducible protein U

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329429.2NP_001316358.1  tumor protein p53-inducible nuclear protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AY422170, CA310159, DB479841
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    Q8IXH6
    Conserved Domains (1) summary
    pfam14839
    Location:67211
    DOR; DOR family
  2. NM_001329430.2NP_001316359.1  tumor protein p53-inducible nuclear protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AY422170, CA310159, HY150218
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    Q8IXH6
    Related
    ENSP00000363942.2, ENST00000374809.6
    Conserved Domains (1) summary
    pfam14839
    Location:67211
    DOR; DOR family
  3. NM_001329431.2NP_001316360.1  tumor protein p53-inducible nuclear protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AL109824, AY422170, CA310159, HY157843
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    Q8IXH6
    Conserved Domains (1) summary
    pfam14839
    Location:67211
    DOR; DOR family
  4. NM_021202.3NP_067025.1  tumor protein p53-inducible nuclear protein 2

    See identical proteins and their annotated locations for NP_067025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript (1). All four variants encode the same protein.
    Source sequence(s)
    AY422170, CA310159
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    Q8IXH6
    Related
    ENSP00000363943.3, ENST00000374810.8
    Conserved Domains (1) summary
    pfam14839
    Location:67211
    DOR; DOR family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    34704344..34713439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723841.2XP_006723904.1  tumor protein p53-inducible nuclear protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006723904.1

    Conserved Domains (1) summary
    pfam14839
    Location:1145
    DOR; DOR family
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