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Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 68652, updated on 24-Oct-2019

Summary

Official Symbol
Tab2provided by MGI
Official Full Name
TGF-beta activated kinase 1/MAP3K7 binding protein 2provided by MGI
Primary source
MGI:MGI:1915902
See related
Ensembl:ENSMUSG00000015755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Map3k7ip2; mKIAA0733; 1110030N06Rik; A530078N03Rik
Expression
Ubiquitous expression in limb E14.5 (RPKM 18.4), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
Orthologs

Genomic context

See Tab2 in Genome Data Viewer
Location:
10; 10 A1
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7905648..7956255, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (7625446..7675921, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 12D Neighboring gene microRNA 5104 Neighboring gene predicted gene, 24726 Neighboring gene predicted gene, 30820 Neighboring gene predicted gene, 30906 Neighboring gene predicted gene, 30959

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
heart development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Names
TGF-beta-activated kinase 1-binding protein 2
Tak1 binding protein 2
mitogen-activated protein kinase kinase kinase 7-interacting protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359534.1NP_001346463.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    AC092856, AW492243, AY093701, CN532534
    Consensus CDS
    CCDS23691.1
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cl25732
    Location:537614
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_138667.3NP_619608.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

    See identical proteins and their annotated locations for NP_619608.1

    Status: VALIDATED

    Source sequence(s)
    AC092856, AK003993, AY093701, BF468714, BG078791, BY429748, CK391470
    Consensus CDS
    CCDS23691.1
    UniProtKB/Swiss-Prot
    Q99K90
    Related
    ENSMUSP00000121266.1, ENSMUST00000146444.7
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cl25732
    Location:537614
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

    Range
    7905648..7956255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243204.3XP_011241506.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011241506.1

    Conserved Domains (4) summary
    smart00547
    Location:693716
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:694713
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cl00087
    Location:561628
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  2. XM_011243203.3XP_011241505.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011241505.1

    Conserved Domains (4) summary
    smart00547
    Location:693716
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:694713
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cl00087
    Location:561628
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  3. XM_030245247.1XP_030101107.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

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