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Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 68652, updated on 9-May-2024

Summary

Official Symbol
Tab2provided by MGI
Official Full Name
TGF-beta activated kinase 1/MAP3K7 binding protein 2provided by MGI
Primary source
MGI:MGI:1915902
See related
Ensembl:ENSMUSG00000015755 AllianceGenome:MGI:1915902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Map3k7ip2; mKIAA0733; 1110030N06Rik; A530078N03Rik
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein kinase activity; and response to lipopolysaccharide. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 18.4), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
Orthologs
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Genomic context

See Tab2 in Genome Data Viewer
Location:
10 A1; 10 2.56 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7781412..7832039, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7905648..7956255, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7559346-7559529 Neighboring gene STARR-seq mESC enhancer starr_25692 Neighboring gene zinc finger CCCH type containing 12D Neighboring gene microRNA 5104 Neighboring gene predicted gene, 24726 Neighboring gene STARR-seq mESC enhancer starr_25693 Neighboring gene STARR-seq mESC enhancer starr_25694 Neighboring gene predicted gene, 30820 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7785616-7785813 Neighboring gene STARR-seq mESC enhancer starr_25695 Neighboring gene STARR-seq mESC enhancer starr_25696 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7904647-7904800 Neighboring gene predicted gene, 30906 Neighboring gene uronyl-2-sulfotransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Names
TGF-beta-activated kinase 1-binding protein 2
Tak1 binding protein 2
mitogen-activated protein kinase kinase kinase 7-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359534.1NP_001346463.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    AC092856, AW492243, AY093701, CN532534
    Consensus CDS
    CCDS23691.1
    UniProtKB/Swiss-Prot
    Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  2. NM_138667.3NP_619608.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

    See identical proteins and their annotated locations for NP_619608.1

    Status: VALIDATED

    Source sequence(s)
    AC092856, AK003993, AY093701, BF468714, BG078791, BY429748, CK391470
    Consensus CDS
    CCDS23691.1
    UniProtKB/Swiss-Prot
    Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4
    Related
    ENSMUSP00000121266.2, ENSMUST00000146444.8
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    7781412..7832039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243204.4XP_011241506.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011241506.1

    Conserved Domains (4) summary
    smart00547
    Location:693716
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:563640
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:694713
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  2. XM_011243203.4XP_011241505.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011241505.1

    Conserved Domains (4) summary
    smart00547
    Location:693716
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:563640
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:694713
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  3. XM_030245247.2XP_030101107.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    Conserved Domains (4) summary
    smart00547
    Location:693716
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:563640
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:694713
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  4. XM_036155973.1XP_036011866.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    Conserved Domains (4) summary
    smart00547
    Location:693716
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:563640
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:694713
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  5. XM_036155974.1XP_036011867.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  6. XM_036155977.1XP_036011870.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    D3Z216
    Conserved Domains (1) summary
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
  7. XM_036155976.1XP_036011869.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    D3Z216
    Conserved Domains (1) summary
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
  8. XM_036155975.1XP_036011868.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    D3Z216
    Conserved Domains (1) summary
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins