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TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 [ Homo sapiens (human) ]

Gene ID: 23118, updated on 4-Oct-2020

Summary

Official Symbol
TAB2provided by HGNC
Official Full Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 2provided by HGNC
Primary source
HGNC:HGNC:17075
See related
Ensembl:ENSG00000055208 Ensembl:ENSG00000228408 MIM:605101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHTD2; TAB-2; MAP3K7IP2
Summary
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in thyroid (RPKM 17.2), esophagus (RPKM 14.8) and 25 other tissues See more
Orthologs

Genomic context

See TAB2 in Genome Data Viewer
Location:
6q25.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (149217926..149411611)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149639436..149732747)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uronyl 2-sulfotransferase Neighboring gene uncharacterized LOC105378046 Neighboring gene small nuclear ribonucleoprotein polypeptide B2 pseudogene Neighboring gene TAB2 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 234, pseudogene Neighboring gene fatty acid binding protein 12 pseudogene 1 Neighboring gene small ubiquitin like modifier 4 Neighboring gene zinc finger CCCH-type containing 12D Neighboring gene coiled-coil domain containing 59 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Congenital heart defects, multiple types, 2
MedGen: C3554279 OMIM: 614980 GeneReviews: Not available
Compare labs
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
GeneReviews: Not available
Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.
GeneReviews: Not available
Genome-wide meta-analysis for severe diabetic retinopathy.
GeneReviews: Not available
Wnt signaling and Dupuytren's disease.
GeneReviews: Not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2020-05-27)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2020-05-27)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2; MAP3K7IP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of TAB-2 PubMed
capsid gag The TAK1 kinase complex (TAK1/TAB2/TAB3) contributes to capsid-specific restriction mediated by TRIM5alpha. TRIM5alpha activates TAK1 autophosphorylation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21885, KIAA0733, DKFZp781G0741

Gene Ontology Provided by GOA

Function Evidence Code Pubs
K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
JNK cascade TAS
Traceable Author Statement
more info
 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 
positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Names
TAK1-binding protein 2
mitogen-activated protein kinase kinase kinase 7-interacting protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021386.2 RefSeqGene

    Range
    105377..198690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001292034.3NP_001278963.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_001278963.1

    Status: REVIEWED

    Source sequence(s)
    AB018276, AL138727, BC035910
    Consensus CDS
    CCDS5214.1
    UniProtKB/Swiss-Prot
    Q9NYJ8
    Related
    ENSP00000490618.1, ENST00000637181.2
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  2. NM_001292035.3NP_001278964.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_001278964.1

    Status: REVIEWED

    Source sequence(s)
    AK295750, BC035910, BX645362
    UniProtKB/Swiss-Prot
    Q9NYJ8
    UniProtKB/TrEMBL
    B4DIR9
    Conserved Domains (3) summary
    smart00547
    Location:635658
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:636655
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cl00087
    Location:502570
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  3. NM_001369506.1NP_001356435.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031133, AL138727, AL139103
    Related
    ENSP00000445752.1, ENST00000538427.5
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  4. NM_015093.6NP_055908.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_055908.1

    Status: REVIEWED

    Source sequence(s)
    AK307650, AK315038, BC035910
    Consensus CDS
    CCDS5214.1
    UniProtKB/Swiss-Prot
    Q9NYJ8
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RNA

  1. NR_125861.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI159838, BX645362, DB467477
    Related
    ENST00000443992.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    149217926..149411611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535633.2XP_011533935.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011533935.1

    UniProtKB/Swiss-Prot
    Q9NYJ8
    Related
    ENSP00000356426.1, ENST00000367456.5
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  2. XM_017010592.2XP_016866081.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NYJ8
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145342.1: Suppressed sequence

    Description
    NM_145342.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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