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TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 [ Homo sapiens (human) ]

Gene ID: 23118, updated on 6-Nov-2022

Summary

Official Symbol
TAB2provided by HGNC
Official Full Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 2provided by HGNC
Primary source
HGNC:HGNC:17075
See related
Ensembl:ENSG00000055208 Ensembl:ENSG00000228408 MIM:605101; AllianceGenome:HGNC:17075
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHTD2; TAB-2; MAP3K7IP2
Summary
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in thyroid (RPKM 17.2), esophagus (RPKM 14.8) and 25 other tissues See more
Orthologs
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Genomic context

See TAB2 in Genome Data Viewer
Location:
6q25.1
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149217926..149411607)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (150417736..150611453)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149539062..149732743)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12512 Neighboring gene uncharacterized LOC124901426 Neighboring gene TAB2 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 234, pseudogene Neighboring gene fatty acid binding protein 12 pseudogene 1 Neighboring gene small ubiquitin like modifier 4 Neighboring gene zinc finger CCCH-type containing 12D Neighboring gene coiled-coil domain containing 59 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Congenital heart defects, multiple types, 2
MedGen: C3554279 OMIM: 614980 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2020-05-27)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2020-05-27)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.
EBI GWAS Catalog
Genome-wide meta-analysis for severe diabetic retinopathy.
EBI GWAS Catalog
Wnt signaling and Dupuytren's disease.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2; MAP3K7IP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of TAB-2 PubMed
capsid gag The TAK1 kinase complex (TAK1/TAB2/TAB3) contributes to capsid-specific restriction mediated by TRIM5alpha. TRIM5alpha activates TAK1 autophosphorylation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21885, KIAA0733, DKFZp781G0741

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Names
TAK1-binding protein 2
mitogen-activated protein kinase kinase kinase 7-interacting protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021386.2 RefSeqGene

    Range
    104789..198684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001292034.3NP_001278963.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_001278963.1

    Status: REVIEWED

    Source sequence(s)
    AB018276, AL138727, BC035910
    Consensus CDS
    CCDS5214.1
    UniProtKB/Swiss-Prot
    Q9NYJ8, Q9UFP7
    Related
    ENSP00000490618.1, ENST00000637181.2
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  2. NM_001292035.3NP_001278964.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_001278964.1

    Status: REVIEWED

    Source sequence(s)
    AK295750, BC035910, BX645362
    UniProtKB/Swiss-Prot
    Q9NYJ8
    UniProtKB/TrEMBL
    B4DIR9
    Conserved Domains (3) summary
    smart00547
    Location:635658
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:636655
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cl00087
    Location:502570
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  3. NM_001369506.1NP_001356435.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031133, AL138727, AL139103
    Consensus CDS
    CCDS5214.1
    UniProtKB/Swiss-Prot
    Q9UFP7
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  4. NM_015093.6NP_055908.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_055908.1

    Status: REVIEWED

    Source sequence(s)
    AK307650, AK315038, BC035910
    Consensus CDS
    CCDS5214.1
    UniProtKB/Swiss-Prot
    Q9NYJ8, Q9UFP7
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RNA

  1. NR_125861.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI159838, BX645362, DB467477
    Related
    ENST00000443992.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    149217926..149411607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535633.3XP_011533935.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011533935.1

    UniProtKB/Swiss-Prot
    Q9NYJ8, Q9UFP7
    Related
    ENSP00000356426.1, ENST00000367456.5
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  2. XM_047418487.1XP_047274443.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9UFP7
  3. XM_047418489.1XP_047274445.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9UFP7
  4. XM_047418486.1XP_047274442.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9UFP7
  5. XM_047418488.1XP_047274444.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9UFP7
  6. XM_017010592.3XP_016866081.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NYJ8, Q9UFP7
    Conserved Domains (4) summary
    smart00547
    Location:667690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    TIGR04523
    Location:537614
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    sd00029
    Location:668687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  7. XM_047418485.1XP_047274441.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9UFP7
  8. XM_047418490.1XP_047274446.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9UFP7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    150417736..150611453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145342.1: Suppressed sequence

    Description
    NM_145342.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.