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Dpm3 dolichyl-phosphate mannosyltransferase polypeptide 3 [ Mus musculus (house mouse) ]

Gene ID: 68563, updated on 9-Mar-2023

Summary

Official Symbol
Dpm3provided by MGI
Official Full Name
dolichyl-phosphate mannosyltransferase polypeptide 3provided by MGI
Primary source
MGI:MGI:1915813
See related
Ensembl:ENSMUSG00000042737 AllianceGenome:MGI:1915813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110001H19Rik
Summary
Predicted to enable enzyme activator activity. Predicted to be involved in GPI anchor biosynthetic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and muscular dystrophy-dystroglycanopathy. Orthologous to human DPM3 (dolichyl-phosphate mannosyltransferase subunit 3, regulatory). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 62.7), mammary gland adult (RPKM 54.3) and 28 other tissues See more
Orthologs
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Genomic context

See Dpm3 in Genome Data Viewer
Location:
3; 3 F1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89166567..89174386)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89257065..89267079)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mucin 1, transmembrane Neighboring gene tripartite motif-containing 46 Neighboring gene keratinocyte associated protein 2 Neighboring gene solute carrier family 50 (sugar transporter), member 1 Neighboring gene ephrin A1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of dolichol-phosphate-mannose synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of dolichol-phosphate-mannose synthase complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dolichol-phosphate mannosyltransferase subunit 3
Names
DPM synthase complex subunit 3
DPM synthase subunit 3
MPD synthase subunit 3
dolichol-phosphate mannose synthase subunit 3
dolichyl-phosphate beta-D-mannosyltransferase subunit 3
mannose-P-dolichol synthase subunit 3
NP_081043.1
XP_006502046.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026767.4NP_081043.1  dolichol-phosphate mannosyltransferase subunit 3 precursor

    See identical proteins and their annotated locations for NP_081043.1

    Status: VALIDATED

    Source sequence(s)
    AI527477, AK003223, CJ237809
    Consensus CDS
    CCDS38487.1
    UniProtKB/Swiss-Prot
    Q9D1Q4
    Related
    ENSMUSP00000040860.2, ENSMUST00000040824.2
    Conserved Domains (1) summary
    pfam08285
    Location:190
    DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89166567..89174386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501983.2XP_006502046.1  dolichol-phosphate mannosyltransferase subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_006502046.1

    UniProtKB/Swiss-Prot
    Q9D1Q4
    Related
    ENSMUSP00000103086.2, ENSMUST00000107462.8
    Conserved Domains (1) summary
    pfam08285
    Location:190
    DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)