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DPM3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory [ Homo sapiens (human) ]

Gene ID: 54344, updated on 3-May-2020

Summary

Official Symbol
DPM3provided by HGNC
Official Full Name
dolichyl-phosphate mannosyltransferase subunit 3, regulatoryprovided by HGNC
Primary source
HGNC:HGNC:3007
See related
Ensembl:ENSG00000179085 MIM:605951
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDG1O
Summary
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 20.5), colon (RPKM 20.2) and 25 other tissues See more
Orthologs

Genomic context

See DPM3 in Genome Data Viewer
Location:
1q22
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155139891..155140573, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155112367..155112996, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ephrin A1 Neighboring gene solute carrier family 50 member 1 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 18 Neighboring gene keratinocyte associated protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34275, MGC125904, MGC125905

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
GPI anchor biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan TAS
Traceable Author Statement
more info
PubMed 
protein N-linked glycosylation via asparagine TAS
Traceable Author Statement
more info
 
protein O-linked mannosylation TAS
Traceable Author Statement
more info
PubMed 
protein mannosylation TAS
Traceable Author Statement
more info
PubMed 
regulation of protein stability IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
dolichol-phosphate-mannose synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dolichol-phosphate-mannose synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
mannosyltransferase complex TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
dolichol-phosphate mannosyltransferase subunit 3
Names
DPM synthase complex subunit 3
DPM synthase subunit 3
MPD synthase subunit 3
dolichol-phosphate mannose synthase subunit 3
dolichyl-phosphate beta-D-mannosyltransferase subunit 3
dolichyl-phosphate mannosyltransferase polypeptide 3
dolichyl-phosphate mannosyltransferase subunit 3
mannose-P-dolichol synthase subunit 3
prostin 1
testicular tissue protein Li 58
NP_061846.2
NP_714963.1
XP_016856987.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012871.1 RefSeqGene

    Range
    4990..5630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018973.3NP_061846.2  dolichol-phosphate mannosyltransferase subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_061846.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF312922
    Consensus CDS
    CCDS1094.1
    UniProtKB/Swiss-Prot
    Q9P2X0
    UniProtKB/TrEMBL
    A0A140VJI4
    Related
    ENSP00000357384.1, ENST00000368399.1
    Conserved Domains (1) summary
    pfam08285
    Location:37121
    DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
  2. NM_153741.2NP_714963.1  dolichol-phosphate mannosyltransferase subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_714963.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. This results in translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL691442
    Consensus CDS
    CCDS1095.1
    UniProtKB/Swiss-Prot
    Q9P2X0
    UniProtKB/TrEMBL
    Q86TM7
    Related
    ENSP00000357385.4, ENST00000368400.4
    Conserved Domains (1) summary
    pfam08285
    Location:791
    DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    155139891..155140573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001498.1XP_016856987.1  dolichol-phosphate mannosyltransferase subunit 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9P2X0
    Related
    ENSP00000344338.3, ENST00000341298.3
    Conserved Domains (1) summary
    pfam08285
    Location:791
    DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
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