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Tefm transcription elongation factor, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 68550, updated on 8-Nov-2022

Summary

Official Symbol
Tefmprovided by MGI
Official Full Name
transcription elongation factor, mitochondrialprovided by MGI
Primary source
MGI:MGI:1915800
See related
Ensembl:ENSMUSG00000046909 AllianceGenome:MGI:1915800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110002N22Rik
Summary
Predicted to enable DNA polymerase processivity factor activity. Predicted to be involved in mitochondrial transcription and oxidative phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrial nucleoid. Orthologous to human TEFM (transcription elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 3.7), CNS E11.5 (RPKM 3.5) and 28 other tissues See more
Orthologs
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Genomic context

See Tefm in Genome Data Viewer
Location:
11 B5; 11 47.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80027500..80033697, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80136674..80142871, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cytokine receptor-like factor 3 Neighboring gene ATPase family, AAA domain containing 5 Neighboring gene ArfGAP with dual PH domains 2 Neighboring gene ring finger protein 135

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ22729

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA polymerase processivity factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA polymerase processivity factor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription elongation by mitochondrial RNA polymerase IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription elongation factor, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183275.2NP_899098.2  transcription elongation factor, mitochondrial

    See identical proteins and their annotated locations for NP_899098.2

    Status: VALIDATED

    Source sequence(s)
    AK146639, BE949440
    Consensus CDS
    CCDS36241.1
    UniProtKB/Swiss-Prot
    Q5SSK3
    Related
    ENSMUSP00000059304.10, ENSMUST00000050207.10
    Conserved Domains (1) summary
    cl22429
    Location:80128
    HHH_5; Helix-hairpin-helix domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    80027500..80033697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249204.3XP_011247506.1  transcription elongation factor, mitochondrial isoform X1

    Conserved Domains (2) summary
    cl21482
    Location:192375
    RuvC_like; Crossover junction endodeoxyribonuclease RuvC and similar proteins
    cl22429
    Location:80128
    HHH_5; Helix-hairpin-helix domain
  2. XM_030246262.1XP_030102122.1  transcription elongation factor, mitochondrial isoform X2

    UniProtKB/TrEMBL
    Q8BTE4
  3. XM_011249205.1XP_011247507.1  transcription elongation factor, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011247507.1

    UniProtKB/TrEMBL
    Q8BTE4