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TEFM transcription elongation factor, mitochondrial [ Homo sapiens (human) ]

Gene ID: 79736, updated on 5-Aug-2022

Summary

Official Symbol
TEFMprovided by HGNC
Official Full Name
transcription elongation factor, mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:26223
See related
Ensembl:ENSG00000172171 MIM:616422; AllianceGenome:HGNC:26223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C17orf42
Summary
Enables DNA polymerase processivity factor activity. Involved in mitochondrial transcription and oxidative phosphorylation. Located in mitochondrial nucleoid. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 3.5), placenta (RPKM 3.5) and 25 other tissues See more
Orthologs
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Genomic context

See TEFM in Genome Data Viewer
Location:
17q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (30898986..30906238, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (31844695..31851947, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29226004..29233256, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S17 pseudogene 3 Neighboring gene ATPase family AAA domain containing 5 Neighboring gene RNA, U6 small nuclear 298, pseudogene Neighboring gene ArfGAP with dual PH domains 2 Neighboring gene RNA, 7SL, cytoplasmic 138, pseudogene Neighboring gene ring finger protein 135

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22729, MGC24674

Gene Ontology Provided by GOA

Process Evidence Code Pubs
NOT involved_in mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription elongation by mitochondrial RNA polymerase IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrial nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription elongation factor, mitochondrial
Names
transcription elongation factor of mitochondria

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024683.4NP_078959.3  transcription elongation factor, mitochondrial

    See identical proteins and their annotated locations for NP_078959.3

    Status: VALIDATED

    Source sequence(s)
    AJ314645, BQ003763, DA647699
    Consensus CDS
    CCDS42291.1
    UniProtKB/Swiss-Prot
    Q96QE5, Q9H5Z9
    Related
    ENSP00000462963.1, ENST00000581216.6
    Conserved Domains (1) summary
    cl22429
    Location:77119
    HHH_5; Helix-hairpin-helix domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    30898986..30906238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722084.3XP_006722147.1  transcription elongation factor, mitochondrial isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    31844695..31851947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)