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Mplkip M-phase specific PLK1 interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 684996, updated on 17-Aug-2024

Summary

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Official Symbol
Mplkipprovided by RGD
Official Full Name
M-phase specific PLK1 interacting proteinprovided by RGD
Primary source
RGD:1584365
See related
EnsemblRapid:ENSRNOG00000013806 AllianceGenome:RGD:1584365
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in centrosome; midbody; and nucleus. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 4. Orthologous to human MPLKIP (M-phase specific PLK1 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 125.4), Testes (RPKM 97.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mplkip in Genome Data Viewer
Location:
17q11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (52069154..52071978, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (47373624..47376199, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (49955060..49990982, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 1, pseudogene 5 Neighboring gene cyclin-dependent kinase 13 Neighboring gene succinylCoA:glutarate-CoA transferase Neighboring gene macrophage migration inhibitory factor, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity. Zhang Y, et al. Cell Mol Life Sci, 2007 Mar. PMID 17310276, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
M-phase-specific PLK1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109452.1 → NP_001102922.1  M-phase-specific PLK1-interacting protein

    See identical proteins and their annotated locations for NP_001102922.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474030
    UniProtKB/TrEMBL
    A6K9A5, D3ZR59, D3ZVR4
    Related
    ENSRNOP00000068955.1, ENSRNOT00000080628.3
    Conserved Domains (1) summary
    pfam15502
    Location:122 → 178
    MPLKIP; M-phase-specific PLK1-interacting protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    52069154..52071978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096069.2 → XP_038951997.1  M-phase-specific PLK1-interacting protein isoform X1

    UniProtKB/TrEMBL
    A6K9A5, D3ZR59, D3ZVR4
    Conserved Domains (1) summary
    pfam15502
    Location:122 → 178
    MPLKIP; M-phase-specific PLK1-interacting protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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