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MPLKIP M-phase specific PLK1 interacting protein [ Homo sapiens (human) ]

Gene ID: 136647, updated on 27-Nov-2024

Summary

Official Symbol
MPLKIPprovided by HGNC
Official Full Name
M-phase specific PLK1 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:16002
See related
Ensembl:ENSG00000168303 MIM:609188; AllianceGenome:HGNC:16002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABHS; TTD4; ORF20; C7orf11
Summary
The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]
Expression
Ubiquitous expression in liver (RPKM 18.5), kidney (RPKM 17.4) and 25 other tissues See more
Orthologs
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Genomic context

See MPLKIP in Genome Data Viewer
Location:
7p14.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (40126027..40134622, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (40283484..40292079, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (40165626..40174221, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18115 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39989224-39990142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18116 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:39991063-39991981 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:40015128-40015628 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:40017861-40018605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25889 Neighboring gene cyclin dependent kinase 13 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:40095303-40095542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18118 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:40186973-40188172 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:40188525-40189421 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 7 Neighboring gene THUMP domain containing 3 pseudogene 1 Neighboring gene succinyl-CoA:glutarate-CoA transferase Neighboring gene uncharacterized LOC105375245

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
M-phase-specific PLK1-interacting protein
Names
Russell-Silver syndrome region
TTD non-photosensitive 1 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016989.2 RefSeqGene

    Range
    5031..13626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_468

mRNA and Protein(s)

  1. NM_138701.4NP_619646.1  M-phase-specific PLK1-interacting protein

    See identical proteins and their annotated locations for NP_619646.1

    Status: REVIEWED

    Source sequence(s)
    AC006023, BC026265, BG501110
    Consensus CDS
    CCDS5463.1
    UniProtKB/Swiss-Prot
    Q8TAP9
    UniProtKB/TrEMBL
    A4D1W6
    Related
    ENSP00000304553.5, ENST00000306984.8
    Conserved Domains (1) summary
    pfam15502
    Location:123179
    MPLKIP; M-phase-specific PLK1-interacting protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    40126027..40134622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    40283484..40292079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)