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MPLKIP M-phase specific PLK1 interacting protein [ Homo sapiens (human) ]

Gene ID: 136647, updated on 20-Dec-2019

Summary

Official Symbol
MPLKIPprovided by HGNC
Official Full Name
M-phase specific PLK1 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:16002
See related
Ensembl:ENSG00000168303 MIM:609188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABHS; TTD4; ORF20; C7orf11
Summary
The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]
Expression
Ubiquitous expression in liver (RPKM 18.5), kidney (RPKM 17.4) and 25 other tissues See more
Orthologs

Genomic context

See MPLKIP in Genome Data Viewer
Location:
7p14.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (40126027..40134622, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (40172342..40174251, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 13 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 7 Neighboring gene THUMP domain containing 3 pseudogene 1 Neighboring gene succinyl-CoA:glutarate-CoA transferase Neighboring gene uncharacterized LOC105375245

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
M-phase-specific PLK1-interacting protein
Names
Russell-Silver syndrome region
TTD non-photosensitive 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016989.2 RefSeqGene

    Range
    5031..13626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138701.4NP_619646.1  M-phase-specific PLK1-interacting protein

    See identical proteins and their annotated locations for NP_619646.1

    Status: REVIEWED

    Source sequence(s)
    AC006023, BC026265, BG501110
    Consensus CDS
    CCDS5463.1
    UniProtKB/Swiss-Prot
    Q8TAP9
    UniProtKB/TrEMBL
    A4D1W6
    Related
    ENSP00000304553.5, ENST00000306984.8
    Conserved Domains (1) summary
    pfam15502
    Location:125179
    MPLKIP; M-phase-specific PLK1-interacting protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    40126027..40134622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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