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Mob1b MOB kinase activator 1B [ Mus musculus (house mouse) ]

Gene ID: 68473, updated on 12-May-2024

Summary

Official Symbol
Mob1bprovided by MGI
Official Full Name
MOB kinase activator 1Bprovided by MGI
Primary source
MGI:MGI:1915723
See related
Ensembl:ENSMUSG00000006262 AllianceGenome:MGI:1915723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mobkl1a; B230364F10; 1110003E08Rik
Summary
Predicted to enable kinase binding activity and protein kinase activator activity. Predicted to be involved in hippo signaling; positive regulation of protein phosphorylation; and regulation of protein autophosphorylation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB1B (MOB kinase activator 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.1), CNS E11.5 (RPKM 4.2) and 28 other tissues See more
Orthologs
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Genomic context

See Mob1b in Genome Data Viewer
Location:
5 E1; 5 43.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (88868730..88906314)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (88720871..88758455)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13573 Neighboring gene STARR-seq mESC enhancer starr_13574 Neighboring gene predicted gene, 42107 Neighboring gene STARR-seq mESC enhancer starr_13575 Neighboring gene RUN and FYVE domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_13576 Neighboring gene STARR-seq mESC enhancer starr_13577 Neighboring gene G-rich RNA sequence binding factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E1682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:89195274-89195480 Neighboring gene predicted gene 15682 Neighboring gene STARR-seq mESC enhancer starr_13581 Neighboring gene deoxycytidine kinase Neighboring gene solute carrier family 4 (anion exchanger), member 4 Neighboring gene makorin, ring finger protein 1, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

General gene information

Markers

Clone Names

  • MGC129510, MGC129511

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
MOB kinase activator 1B
Names
MOB1, Mps One Binder kinase activator-like 1A
mob1 homolog 1A
mps one binder kinase activator-like 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026735.2NP_081011.1  MOB kinase activator 1B

    See identical proteins and their annotated locations for NP_081011.1

    Status: VALIDATED

    Source sequence(s)
    AK042552, AK077320, AK162120
    Consensus CDS
    CCDS39139.1
    UniProtKB/Swiss-Prot
    Q8BPB0
    UniProtKB/TrEMBL
    Q3T9U1, Q3UDM0
    Related
    ENSMUSP00000006424.8, ENSMUST00000006424.8
    Conserved Domains (1) summary
    pfam03637
    Location:33204
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    88868730..88906314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)