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MOB1B MOB kinase activator 1B [ Homo sapiens (human) ]

Gene ID: 92597, updated on 7-Jun-2020

Summary

Official Symbol
MOB1Bprovided by HGNC
Official Full Name
MOB kinase activator 1Bprovided by HGNC
Primary source
HGNC:HGNC:29801
See related
Ensembl:ENSG00000173542 MIM:609282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MATS2; MOB4A; MOBKL1A
Summary
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in kidney (RPKM 9.7), bone marrow (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See MOB1B in Genome Data Viewer
Location:
4q13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (70901970..70988174)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71768043..71853891)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 891, pseudogene Neighboring gene G-rich RNA sequence binding factor 1 Neighboring gene deoxycytidine kinase Neighboring gene solute carrier family 4 member 4 Neighboring gene probable UDP-sugar transporter protein SLC35A4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33910

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
hippo signaling TAS
Traceable Author Statement
more info
 
positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MOB kinase activator 1B
Names
MOB1 Mps One Binder homolog B
MOB1, Mps One Binder kinase activator-like 1A
mob1 homolog 1A
mob1A
mps one binder kinase activator-like 1A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244766.2NP_001231695.1  MOB kinase activator 1B isoform 1

    See identical proteins and their annotated locations for NP_001231695.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC021989, AC093851, AK299481
    Consensus CDS
    CCDS58903.1
    UniProtKB/Swiss-Prot
    Q7L9L4
    Related
    ENSP00000379366.2, ENST00000396051.2
    Conserved Domains (1) summary
    pfam03637
    Location:38209
    Mob1_phocein; Mob1/phocein family
  2. NM_001244767.2NP_001231696.1  MOB kinase activator 1B isoform 3

    See identical proteins and their annotated locations for NP_001231696.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC108014, AK093545
    UniProtKB/TrEMBL
    B3KSH6
    Related
    ENST00000509041.5
    Conserved Domains (1) summary
    pfam03637
    Location:33139
    Mob1_phocein; Mob1/phocein family
  3. NM_173468.4NP_775739.1  MOB kinase activator 1B isoform 2

    See identical proteins and their annotated locations for NP_775739.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC021989, AC093851, BC038112
    Consensus CDS
    CCDS34002.1
    UniProtKB/Swiss-Prot
    Q7L9L4
    Related
    ENSP00000310189.2, ENST00000309395.6
    Conserved Domains (1) summary
    pfam03637
    Location:33204
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    70901970..70988174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532412.2XP_011530714.1  MOB kinase activator 1B isoform X2

    Conserved Domains (1) summary
    pfam03637
    Location:57228
    Mob1_phocein; Mob1/phocein family
  2. XM_005265709.2XP_005265766.1  MOB kinase activator 1B isoform X3

    See identical proteins and their annotated locations for XP_005265766.1

    UniProtKB/Swiss-Prot
    Q7L9L4
    Conserved Domains (1) summary
    pfam03637
    Location:38209
    Mob1_phocein; Mob1/phocein family
  3. XM_017008837.1XP_016864326.1  MOB kinase activator 1B isoform X1

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