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Rpa1 replication protein A1 [ Mus musculus (house mouse) ]

Gene ID: 68275, updated on 9-Mar-2023

Summary

Official Symbol
Rpa1provided by MGI
Official Full Name
replication protein A1provided by MGI
Primary source
MGI:MGI:1915525
See related
Ensembl:ENSMUSG00000000751 AllianceGenome:MGI:1915525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpa; RF-A; RP-A; 70kDa; 5031405K23Rik
Summary
Enables chromatin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; homeostasis of number of cells within a tissue; and in utero embryonic development. Located in lateral element and male germ cell nucleus. Is expressed in respiratory system; submandibular gland; testis; and ventricular layer. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 24.0), liver E14.5 (RPKM 21.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rpa1 in Genome Data Viewer
Location:
11 B5; 11 45.79 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75191085..75239478, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75300259..75348454, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene reticulon 4 receptor-like 1 Neighboring gene predicted gene, 35169 Neighboring gene predicted gene, 35117 Neighboring gene SET and MYND domain containing 4 Neighboring gene serine (or cysteine) peptidase inhibitor, clade F, member 1 Neighboring gene predicted gene, 35337

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mismatch repair ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to chromosome ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of DNA replication factor A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of DNA replication factor A complex ISO
Inferred from Sequence Orthology
more info
 
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral element IDA
Inferred from Direct Assay
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
replication protein A 70 kDa DNA-binding subunit
Names
RF-A protein 1
RP-A p70
replication factor A protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164223.1NP_001157695.1  replication protein A 70 kDa DNA-binding subunit isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK148035, AK152296, BE981198, CJ078143, CJ086677
    Consensus CDS
    CCDS48847.1
    UniProtKB/Swiss-Prot
    Q8VEE4
    UniProtKB/TrEMBL
    Q3U8B3, Q5SWN2
    Related
    ENSMUSP00000000767.6, ENSMUST00000000767.6
    Conserved Domains (5) summary
    cd04474
    Location:216318
    RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    cd04475
    Location:346446
    RPA1_DBD_B; RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    TIGR00617
    Location:2642
    rpa1; replication factor-a protein 1 (rpa1)
    pfam04057
    Location:5125
    Rep-A_N; Replication factor-A protein 1, N-terminal domain
    pfam08646
    Location:491636
    Rep_fac-A_C; Replication factor-A C terminal domain
  2. NM_026653.2NP_080929.1  replication protein A 70 kDa DNA-binding subunit isoform 2

    See identical proteins and their annotated locations for NP_080929.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an alternate segment, compared to isoform 1.
    Source sequence(s)
    AK148035, BE981198, CJ078143, CJ086677
    Consensus CDS
    CCDS25044.1
    UniProtKB/Swiss-Prot
    Q3TEJ8, Q8VEE4
    Related
    ENSMUSP00000090585.6, ENSMUST00000092907.12
    Conserved Domains (5) summary
    cd04474
    Location:195297
    RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    cd04475
    Location:325425
    RPA1_DBD_B; RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    TIGR00617
    Location:2621
    rpa1; replication factor-a protein 1 (rpa1)
    pfam04057
    Location:5104
    Rep-A_N; Replication factor-A protein 1, N-terminal domain
    pfam08646
    Location:470615
    Rep_fac-A_C; Replication factor-A C terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75191085..75239478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534051.3XP_006534114.1  replication protein A 70 kDa DNA-binding subunit isoform X1

    Conserved Domains (1) summary
    TIGR00617
    Location:2650
    rpa1; replication factor-a protein 1 (rpa1)