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Efcab2 EF-hand calcium binding domain 2 [ Mus musculus (house mouse) ]

Gene ID: 68226, updated on 18-Apr-2024

Summary

Official Symbol
Efcab2provided by MGI
Official Full Name
EF-hand calcium binding domain 2provided by MGI
Primary source
MGI:MGI:1915476
See related
Ensembl:ENSMUSG00000026495 AllianceGenome:MGI:1915476
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700073K01Rik; D830011E08Rik
Summary
Enables calcium ion binding activity. Located in sperm principal piece. Is expressed in several structures, including endocrine gland; forelimb bud; genitourinary system; lung; and nervous system. Orthologous to human EFCAB2 (EF-hand calcium binding domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 5.9), heart adult (RPKM 4.2) and 15 other tissues See more
Orthologs
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Genomic context

Location:
1 H4; 1 83.16 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (178233583..178312078)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (178406018..178484513)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03149 Neighboring gene heterogeneous nuclear ribonucleoprotein U Neighboring gene cytochrome c oxidase assembly protein 20 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:180299062-180299171 Neighboring gene STARR-positive B cell enhancer ABC_E10066 Neighboring gene predicted gene, 24919 Neighboring gene STARR-seq mESC enhancer starr_03153 Neighboring gene predicted gene, 53484 Neighboring gene STARR-positive B cell enhancer ABC_E8780 Neighboring gene STARR-seq mESC enhancer starr_03154 Neighboring gene predicted gene, 31289 Neighboring gene predicted gene, 39709

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynein regulatory complex protein 8
Names
EF-hand calcium-binding domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026626.3NP_080902.1  dynein regulatory complex protein 8

    See identical proteins and their annotated locations for NP_080902.1

    Status: VALIDATED

    Source sequence(s)
    AC157809
    Consensus CDS
    CCDS15557.1
    UniProtKB/Swiss-Prot
    Q9CQ46, Q9CS07
    Related
    ENSMUSP00000027775.8, ENSMUST00000027775.9
    Conserved Domains (2) summary
    PTZ00184
    Location:10160
    PTZ00184; calmodulin; Provisional
    cl08302
    Location:99159
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    178233583..178312078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)