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SULT2A1 sulfotransferase family 2A member 1 [ Homo sapiens (human) ]

Gene ID: 6822, updated on 7-Dec-2018

Summary

Official Symbol
SULT2A1provided by HGNC
Official Full Name
sulfotransferase family 2A member 1provided by HGNC
Primary source
HGNC:HGNC:11458
See related
Ensembl:ENSG00000105398 MIM:125263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HST; ST2; STD; hSTa; DHEAS; ST2A1; ST2A3; DHEA-ST
Summary
This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]
Expression
Biased expression in liver (RPKM 300.0), adrenal (RPKM 86.0) and 2 other tissues See more
Orthologs

Genomic context

See SULT2A1 in Genome Data Viewer
Location:
19q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (47870466..47886397, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48373723..48389654, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene tetrapeptide repeat homeobox 2, pseudogene Neighboring gene long intergenic non-protein coding RNA 1595 Neighboring gene small NF90 (ILF3) associated RNA A12 Neighboring gene small NF90 (ILF3) associated RNA C5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aryl sulfotransferase activity TAS
Traceable Author Statement
more info
 
bile-salt sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
estrone sulfotransferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
steroid sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
steroid sulfotransferase activity TAS
Traceable Author Statement
more info
 
sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
sulfotransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
bile acid catabolic process IEA
Inferred from Electronic Annotation
more info
 
ethanol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
steroid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
sulfation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
bile salt sulfotransferase
Names
alcohol/hydroxysteroid sulfotransferase
bile-salt sulfotranasferase 2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
NP_003158.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016745.1 RefSeqGene

    Range
    5001..20932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003167.4NP_003158.2  bile salt sulfotransferase

    See identical proteins and their annotated locations for NP_003158.2

    Status: REVIEWED

    Source sequence(s)
    AC024582, BC020755, BX509490
    Consensus CDS
    CCDS12707.1
    UniProtKB/Swiss-Prot
    Q06520
    UniProtKB/TrEMBL
    A8K015
    Related
    ENSP00000222002.2, ENST00000222002.3
    Conserved Domains (1) summary
    pfam00685
    Location:34278
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    47870466..47886397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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