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Denr density-regulated protein [ Mus musculus (house mouse) ]

Gene ID: 68184, updated on 11-Mar-2023

Summary

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Official Symbol
Denrprovided by MGI
Official Full Name
density-regulated proteinprovided by MGI
Primary source
MGI:MGI:1915434
See related
Ensembl:ENSMUSG00000023106 AllianceGenome:MGI:1915434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500003K04Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Predicted to act upstream of or within translational initiation. Is expressed in embryo. Orthologous to human DENR (density regulated re-initiation and release factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 21.0), liver E14 (RPKM 12.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Denr in Genome Data Viewer
Location:
5; 5 F
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124045227..124066895)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123907205..123928832)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydroxycarboxylic acid receptor 2 Neighboring gene hydrocarboxylic acid receptor 1 Neighboring gene coiled-coil domain containing 62 Neighboring gene predicted gene, 46922 Neighboring gene huntingtin interacting protein 1 related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock. Castelo-Szekely V, et al. Nucleic Acids Res, 2019 Jun 4. PMID 30982898, Free PMC Article
  2. De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation. Haas MA, et al. Cell Rep, 2016 Jun 7. PMID 27239039, Free PMC Article
  3. An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Korobova F, et al. Science, 2013 Jan 25. PMID 23349293, Free PMC Article
  4. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
  5. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clock is a DENR target in mouse circadian timekeeping
    Title: Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock.
  2. Denr influences the migration of murine cerebral cortical neurons in vivo with its binding partner Mcts1.
    Title: De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRES-dependent viral translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in formation of translation preinitiation complex ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation reinitiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
density-regulated protein
Names
DRP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417688.1 → NP_001404617.1  density-regulated protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122753

  2. NM_001417689.1 → NP_001404618.1  density-regulated protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122753

  3. NM_001417690.1 → NP_001404619.1  density-regulated protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AC122753

  4. NM_001417691.1 → NP_001404620.1  density-regulated protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AC122753

  5. NM_001417692.1 → NP_001404621.1  density-regulated protein isoform d

    Status: VALIDATED

    Source sequence(s)
    AC122753

  6. NM_026603.5 → NP_080879.1  density-regulated protein isoform a

    See identical proteins and their annotated locations for NP_080879.1

    Status: VALIDATED

    Source sequence(s)
    AC122753
    Consensus CDS
    CCDS39275.1
    UniProtKB/Swiss-Prot
    Q3UXY1, Q9CQJ6
    UniProtKB/TrEMBL
    A0A6P5PXA6
    Related
    ENSMUSP00000023869.9, ENSMUST00000023869.15
    Conserved Domains (1) summary
    TIGR01159
    Location:28 → 193
    DRP1; density-regulated protein DRP1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124045227..124066895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530452.4 → XP_006530515.1  density-regulated protein isoform X1

    Conserved Domains (1) summary
    cl00229
    Location:12 → 163
    eIF1_SUI1_like; Eukaryotic initiation factor 1 and related proteins

  2. XM_011248238.3 → XP_011246540.1  density-regulated protein isoform X2

    Conserved Domains (1) summary
    cl00229
    Location:1 → 147
    eIF1_SUI1_like; Eukaryotic initiation factor 1 and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQJ6.1 GenPept UniProtKB/Swiss-Prot:Q9CQJ6

Gene LinkOut

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