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DENR density regulated re-initiation and release factor [ Homo sapiens (human) ]

Gene ID: 8562, updated on 1-Jun-2020

Summary

Official Symbol
DENRprovided by HGNC
Official Full Name
density regulated re-initiation and release factorprovided by HGNC
Primary source
HGNC:HGNC:2769
See related
Ensembl:ENSG00000139726 MIM:604550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRP; DRP1; SMAP-3
Summary
This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 16.4), lymph node (RPKM 16.3) and 25 other tissues See more
Orthologs

Genomic context

See DENR in Genome Data Viewer
Location:
12q24.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (122752824..122771064)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123237371..123255953)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene hydroxycarboxylic acid receptor 1 Neighboring gene Sharpr-MPRA regulatory region 1215 Neighboring gene coiled-coil domain containing 62 Neighboring gene huntingtin interacting protein 1 related

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
IRES-dependent viral translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
formation of translation preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 
ribosome disassembly IDA
Inferred from Direct Assay
more info
PubMed 
translation reinitiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
density-regulated protein
Names
smooth muscle cell associated protein-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003677.5NP_003668.2  density-regulated protein

    See identical proteins and their annotated locations for NP_003668.2

    Status: REVIEWED

    Source sequence(s)
    AB014731, AF103800, AI093455, BP872988, CB043904, CN300034
    Consensus CDS
    CCDS45003.1
    UniProtKB/Swiss-Prot
    O43583
    UniProtKB/TrEMBL
    A0A024RBR3
    Related
    ENSP00000280557.6, ENST00000280557.11
    Conserved Domains (1) summary
    TIGR01159
    Location:28193
    DRP1; density-regulated protein DRP1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    122752824..122771064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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