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SULT1A1 sulfotransferase family 1A member 1 [ Homo sapiens (human) ]

Gene ID: 6817, updated on 13-Jan-2019

Summary

Official Symbol
SULT1A1provided by HGNC
Official Full Name
sulfotransferase family 1A member 1provided by HGNC
Primary source
HGNC:HGNC:11453
See related
Ensembl:ENSG00000196502 MIM:171150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; HAST1/HAST2
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in duodenum (RPKM 44.2), liver (RPKM 36.4) and 22 other tissues See more
Orthologs

Genomic context

See SULT1A1 in Genome Data Viewer
Location:
16p11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (28605587..28623586, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28616908..28634907, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene SAGA complex associated factor 29 Neighboring gene sulfotransferase family 1A member 2 Neighboring gene uncharacterized LOC107984835 Neighboring gene nuclear pore complex interacting protein family member B8 Neighboring gene eukaryotic translation initiation factor 3 subunit C Neighboring gene cell division cycle 37 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Common variants at five new loci associated with early-onset inflammatory bowel disease.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5163, MGC131921

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
aryl sulfotransferase activity TAS
Traceable Author Statement
more info
 
flavonol 3-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
steroid sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
amine metabolic process TAS
Traceable Author Statement
more info
PubMed 
catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
estrogen metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ethanol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
flavonoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
sulfation IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sulfotransferase 1A1
Names
P-PST 1
aryl sulfotransferase 1
phenol-sulfating phenol sulfotransferase 1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
thermostable phenol sulfotransferase1
ts-PST
NP_001046.2
NP_803565.1
NP_803566.1
NP_803878.1
NP_803880.1
XP_016879093.1
XP_016879094.1
XP_016879096.1
XP_016879097.1
XP_016879098.1
XP_016879099.1
XP_016879100.1
XP_016879101.1
XP_016879102.1
XP_024306176.1
XP_024306177.1
XP_024306178.1
XP_024306179.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028128.1 RefSeqGene

    Range
    19218..22959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001055.3NP_001046.2  sulfotransferase 1A1 isoform a

    See identical proteins and their annotated locations for NP_001046.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    BC000923, BG482944, BM984308, U26309
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225
    Related
    ENSP00000321988.7, ENST00000314752.11
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  2. NM_177529.2NP_803565.1  sulfotransferase 1A1 isoform a

    See identical proteins and their annotated locations for NP_803565.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AJ007418, BG482944, BM927749, BM984308, BT007324
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225
    Related
    ENSP00000456459.1, ENST00000566189.5
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  3. NM_177530.2NP_803566.1  sulfotransferase 1A1 isoform a

    See identical proteins and their annotated locations for NP_803566.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC020765, AJ007418, BG990719, BM984308, BT007324, CV023878
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225
    Related
    ENSP00000378971.1, ENST00000395607.5
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  4. NM_177534.2NP_803878.1  sulfotransferase 1A1 isoform a

    See identical proteins and their annotated locations for NP_803878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC020765, BM984308, BT007324, U26309
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225
    Related
    ENSP00000457912.1, ENST00000569554.5
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  5. NM_177536.3NP_803880.1  sulfotransferase 1A1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1, which causes the predicted protein (isoform b) to be shorter than isoform a. The predicted ORF of this rare transcript has not been experimentally confirmed.
    Source sequence(s)
    AC020765, BM984308
    Consensus CDS
    CCDS10637.1
    UniProtKB/Swiss-Prot
    P50225
    Related
    ENSP00000329399.4, ENST00000350842.8
    Conserved Domains (1) summary
    pfam00685
    Location:47209
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    28605587..28623586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023613.2XP_016879102.1  sulfotransferase 1A1 isoform X4

    UniProtKB/Swiss-Prot
    P50225
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_017023612.2XP_016879101.1  sulfotransferase 1A1 isoform X4

    UniProtKB/Swiss-Prot
    P50225
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  3. XM_024450410.1XP_024306178.1  sulfotransferase 1A1 isoform X4

    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  4. XM_024450411.1XP_024306179.1  sulfotransferase 1A1 isoform X4

    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  5. XM_017023611.2XP_016879100.1  sulfotransferase 1A1 isoform X4

    UniProtKB/Swiss-Prot
    P50225
    Related
    ENSP00000378972.1, ENST00000395609.5
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  6. XM_024450408.1XP_024306176.1  sulfotransferase 1A1 isoform X2

    Conserved Domains (1) summary
    pfam00685
    Location:130379
    Sulfotransfer_1; Sulfotransferase domain
  7. XM_024450409.1XP_024306177.1  sulfotransferase 1A1 isoform X4

    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  8. XM_017023607.2XP_016879096.1  sulfotransferase 1A1 isoform X3

  9. XM_017023605.1XP_016879094.1  sulfotransferase 1A1 isoform X1

  10. XM_017023604.1XP_016879093.1  sulfotransferase 1A1 isoform X1

  11. XM_017023608.1XP_016879097.1  sulfotransferase 1A1 isoform X1

  12. XM_017023609.1XP_016879098.1  sulfotransferase 1A1 isoform X1

  13. XM_017023610.1XP_016879099.1  sulfotransferase 1A1 isoform X1

RNA

  1. XR_001751973.1 RNA Sequence

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