U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 [ Mus musculus (house mouse) ]

Gene ID: 20887, updated on 1-Mar-2024

Summary

Official Symbol
Sult1a1provided by MGI
Official Full Name
sulfotransferase family 1A, phenol-preferring, member 1provided by MGI
Primary source
MGI:MGI:102896
See related
Ensembl:ENSMUSG00000030711 AllianceGenome:MGI:102896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PST; Stp; Stp1; ST1A1; ST1A4; mSTp1
Summary
Enables nucleotide binding activity and sulfotransferase activity. Acts upstream of or within sulfation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in adrenal gland; central nervous system; gland; meninges; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 40.1), liver E18 (RPKM 24.9) and 18 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Sult1a1 in Genome Data Viewer
Location:
7 F3; 7 69.25 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126272042..126289615, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126672865..126690443, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39087 Neighboring gene nuclear protein transcription regulator 1 Neighboring gene SAGA complex associated factor 29 Neighboring gene STARR-seq mESC enhancer starr_20153 Neighboring gene STARR-positive B cell enhancer ABC_E6601 Neighboring gene sulfotransferase family 1A, phenol-preferring, member 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3751 Neighboring gene STARR-positive B cell enhancer ABC_E2252 Neighboring gene SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133845996-133846179 Neighboring gene STARR-positive B cell enhancer ABC_E10475 Neighboring gene bolA family member 2 Neighboring gene coronin, actin binding protein 1A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables amine sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aryl sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables flavonol 3-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables sulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tyrosine-ester sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 4-nitrophenol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in catecholamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sulfation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sulfation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in sulfation ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sulfotransferase 1A1
Names
aryl sulfotransferase
arylsulfotransferase ST1A4
phenol sulfotransferase
phenol/aryl sulfotransferase
sulfokinase
sulfotransferase, phenol preferring 1
NP_001390060.1
NP_598431.2
XP_006507601.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403131.1NP_001390060.1  sulfotransferase 1A1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124505
  2. NM_133670.3NP_598431.2  sulfotransferase 1A1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS40128.2
    UniProtKB/TrEMBL
    E9QNL5, Q9R1S5
    Related
    ENSMUSP00000101981.3, ENSMUST00000106373.9
    Conserved Domains (1) summary
    pfam00685
    Location:41291
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126272042..126289615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507538.5XP_006507601.1  sulfotransferase 1A1 isoform X1

    See identical proteins and their annotated locations for XP_006507601.1

    UniProtKB/TrEMBL
    E9QNL5, Q9R1S5
    Conserved Domains (1) summary
    pfam00685
    Location:41291
    Sulfotransfer_1; Sulfotransferase domain