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STX5 syntaxin 5 [ Homo sapiens (human) ]

Gene ID: 6811, updated on 7-Jun-2020

Summary

Official Symbol
STX5provided by HGNC
Official Full Name
syntaxin 5provided by HGNC
Primary source
HGNC:HGNC:11440
See related
Ensembl:ENSG00000162236 MIM:603189
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SED5; STX5A
Summary
This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in thyroid (RPKM 22.3), ovary (RPKM 17.5) and 25 other tissues See more
Orthologs

Genomic context

See STX5 in Genome Data Viewer
Location:
11q12.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62806860..62832053, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62574332..62599563, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 179B Neighboring gene transmembrane protein 223 Neighboring gene microRNA 6514 Neighboring gene nuclear RNA export factor 1 Neighboring gene RNA, U6 small nuclear 118, pseudogene Neighboring gene uncharacterized LOC105369332 Neighboring gene WD repeat domain 74 Neighboring gene RNA, U2 small nuclear 2, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of syntaxin 5 (STX5) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNAP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding HDA PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
 
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
Golgi disassembly IDA
Inferred from Direct Assay
more info
PubMed 
early endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Golgi organization IDA
Inferred from Direct Assay
more info
PubMed 
retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
PubMed 
vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion with Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex TAS
Traceable Author Statement
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
syntaxin-5
Names
syntaxin 5A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030034.1 RefSeqGene

    Range
    5041..30232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001244666.2NP_001231595.1  syntaxin-5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift and early stop codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC002645, BE409085, CB155395
    Consensus CDS
    CCDS58140.1
    UniProtKB/Swiss-Prot
    Q13190
    Related
    ENSP00000367129.4, ENST00000377897.8
    Conserved Domains (3) summary
    COG5325
    Location:94301
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    pfam11416
    Location:5374
    Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
    cl22856
    Location:266304
    SNARE; SNARE motif
  2. NM_001330294.2NP_001317223.1  syntaxin-5 isoform 3

    Status: REVIEWED

    Source sequence(s)
    BE409085, BI820950, BT019647, BX537426
    Consensus CDS
    CCDS81578.1
    UniProtKB/Swiss-Prot
    Q13190
    Related
    ENSP00000378182.1, ENST00000394690.5
    Conserved Domains (3) summary
    COG5325
    Location:128270
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15844
    Location:212284
    SNARE_syntaxin5; SNARE motif of syntaxin 5
    pfam11416
    Location:120
    Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
  3. NM_003164.5NP_003155.2  syntaxin-5 isoform 1

    See identical proteins and their annotated locations for NP_003155.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    BE409085, CB155395, U26648
    Consensus CDS
    CCDS8038.2
    UniProtKB/Swiss-Prot
    Q13190
    Related
    ENSP00000294179.3, ENST00000294179.8
    Conserved Domains (3) summary
    COG5325
    Location:182324
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15844
    Location:266338
    SNARE_syntaxin5; SNARE motif of syntaxin 5
    pfam11416
    Location:5374
    Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62806860..62832053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545224.3XP_011543526.1  syntaxin-5 isoform X1

    See identical proteins and their annotated locations for XP_011543526.1

    UniProtKB/TrEMBL
    B4DKR0
    Conserved Domains (2) summary
    cd15844
    Location:170242
    SNARE_syntaxin5; SNARE motif of syntaxin 5
    cl26014
    Location:86228
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
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