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STX3 syntaxin 3 [ Homo sapiens (human) ]

Gene ID: 6809, updated on 29-Mar-2020

Summary

Official Symbol
STX3provided by HGNC
Official Full Name
syntaxin 3provided by HGNC
Primary source
HGNC:HGNC:11438
See related
Ensembl:ENSG00000166900 MIM:600876
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STX3A
Summary
The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in colon (RPKM 9.8), duodenum (RPKM 8.8) and 25 other tissues See more
Orthologs

Genomic context

See STX3 in Genome Data Viewer
Location:
11q12.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (59755374..59805879)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (59522479..59573355)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily V member 3 pseudogene Neighboring gene olfactory receptor family 10 subfamily V member 2 pseudogene Neighboring gene fatty acid binding protein 5 pseudogene 7 Neighboring gene mitochondrial ribosomal protein L16 Neighboring gene cobalamin binding intrinsic factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30906

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
exocytic insertion of neurotransmitter receptor to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle docking IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
azurophil granule IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
specific granule IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vacuole TAS
Traceable Author Statement
more info
PubMed 
zymogen granule membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
syntaxin-3
Names
syntaxin 3A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047082.1 RefSeqGene

    Range
    5318..55820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178040.2NP_001171511.1  syntaxin-3 isoform 2

    See identical proteins and their annotated locations for NP_001171511.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA858058, AK125660, AK297419, AP000640
    Consensus CDS
    CCDS53637.1
    UniProtKB/Swiss-Prot
    Q13277
    UniProtKB/TrEMBL
    Q53YE2
    Related
    ENSP00000433248.1, ENST00000529177.5
    Conserved Domains (3) summary
    cd00179
    Location:32181
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15881
    Location:190258
    SNARE_syntaxin3; SNARE motif of syntaxin 3
    pfam00804
    Location:32226
    Syntaxin; Syntaxin
  2. NM_004177.5NP_004168.1  syntaxin-3 isoform 1

    See identical proteins and their annotated locations for NP_004168.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA858058, AK125660, AP000640, BC007405
    Consensus CDS
    CCDS7975.1
    UniProtKB/Swiss-Prot
    Q13277
    UniProtKB/TrEMBL
    Q53YE2
    Related
    ENSP00000338562.4, ENST00000337979.9
    Conserved Domains (2) summary
    pfam00804
    Location:32226
    Syntaxin; Syntaxin
    cl22856
    Location:194260
    SNARE; SNARE motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    59755374..59805879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018196.1XP_016873685.1  syntaxin-3 isoform X9

  2. XM_011545221.2XP_011543523.1  syntaxin-3 isoform X8

    Conserved Domains (2) summary
    cd00179
    Location:184
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15881
    Location:93161
    SNARE_syntaxin3; SNARE motif of syntaxin 3
  3. XM_005274198.3XP_005274255.1  syntaxin-3 isoform X4

    See identical proteins and their annotated locations for XP_005274255.1

    Conserved Domains (3) summary
    cd00179
    Location:32181
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15881
    Location:190258
    SNARE_syntaxin3; SNARE motif of syntaxin 3
    pfam00804
    Location:32226
    Syntaxin; Syntaxin
  4. XM_005274200.4XP_005274257.1  syntaxin-3 isoform X7

    See identical proteins and their annotated locations for XP_005274257.1

    UniProtKB/Swiss-Prot
    Q13277
    Conserved Domains (3) summary
    cd00179
    Location:32181
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    pfam00804
    Location:32225
    Syntaxin; Syntaxin
    cl22856
    Location:190225
    SNARE; SNARE motif
  5. XM_005274195.4XP_005274252.1  syntaxin-3 isoform X3

    See identical proteins and their annotated locations for XP_005274252.1

    UniProtKB/Swiss-Prot
    Q13277
    UniProtKB/TrEMBL
    Q53YE2
    Conserved Domains (2) summary
    pfam00804
    Location:32226
    Syntaxin; Syntaxin
    cl22856
    Location:194260
    SNARE; SNARE motif
  6. XM_017018192.1XP_016873681.1  syntaxin-3 isoform X2

  7. XM_017018193.1XP_016873682.1  syntaxin-3 isoform X2

  8. XM_017018191.1XP_016873680.1  syntaxin-3 isoform X1

  9. XM_017018189.1XP_016873678.1  syntaxin-3 isoform X1

  10. XM_017018188.1XP_016873677.1  syntaxin-3 isoform X1

    Related
    ENSP00000493027.1, ENST00000641815.1
  11. XM_017018194.1XP_016873683.1  syntaxin-3 isoform X5

  12. XM_017018195.1XP_016873684.1  syntaxin-3 isoform X6

    Related
    ENSP00000431386.1, ENST00000528805.1
  13. XM_017018190.1XP_016873679.1  syntaxin-3 isoform X1

RNA

  1. XR_001747944.2 RNA Sequence

    Related
    ENST00000633708.1
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