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Pdzd2 PDZ domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 68070, updated on 5-Mar-2024

Summary

Official Symbol
Pdzd2provided by MGI
Official Full Name
PDZ domain containing 2provided by MGI
Primary source
MGI:MGI:1922394
See related
Ensembl:ENSMUSG00000022197 AllianceGenome:MGI:1922394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm82; Pdzk3; Gm21706; 4930537L06Rik; A930022H17Rik
Summary
Predicted to be located in several cellular components, including cell-cell junction; centriolar satellite; and postsynaptic density. Is expressed in brain. Orthologous to human PDZD2 (PDZ domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 19.6), subcutaneous fat pad adult (RPKM 4.3) and 13 other tissues See more
Orthologs
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Genomic context

Location:
15 A1; 15 5.9 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (12359797..12740052, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (12359711..12739968, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38019 Neighboring gene predicted gene, 46497 Neighboring gene predicted gene, 52210 Neighboring gene golgi phosphoprotein 3 Neighboring gene STARR-seq mESC enhancer starr_38020 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:12365796-12365983 Neighboring gene STARR-seq mESC enhancer starr_38025 Neighboring gene predicted gene, 52211 Neighboring gene STARR-seq mESC enhancer starr_38027 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_38028 Neighboring gene predicted gene, 41273 Neighboring gene STARR-seq mESC enhancer starr_38031 Neighboring gene STARR-seq mESC enhancer starr_38032 Neighboring gene STARR-positive B cell enhancer ABC_E4128 Neighboring gene predicted gene, 17756 Neighboring gene predicted gene, 41274

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Endonuclease-mediated (3) 

General gene information

Markers

Clone Names

  • KIAA0300

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
PDZ domain-containing protein 2
Names
PDZ domain containing 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081064.2NP_001074533.1  PDZ domain-containing protein 2

    See identical proteins and their annotated locations for NP_001074533.1

    Status: VALIDATED

    Source sequence(s)
    AC133282, AC135292, AC150660
    Consensus CDS
    CCDS37045.1
    UniProtKB/TrEMBL
    E9Q1M1
    Conserved Domains (4) summary
    smart00228
    Location:27092791
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:11971562
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:10501355
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:591672
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    12359797..12740052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520163.5XP_006520226.1  PDZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006520226.1

    UniProtKB/TrEMBL
    E9Q1M1
    Conserved Domains (4) summary
    smart00228
    Location:27092791
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:11971562
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:10501355
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:591672
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_006520167.4XP_006520230.1  PDZ domain-containing protein 2 isoform X4

    Conserved Domains (4) summary
    smart00228
    Location:25652647
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:10531418
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:9061211
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:447528
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_006520166.4XP_006520229.1  PDZ domain-containing protein 2 isoform X3

    Conserved Domains (4) summary
    smart00228
    Location:26172699
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:11051470
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:9581263
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:499580
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_017316735.3XP_017172224.1  PDZ domain-containing protein 2 isoform X7

    Conserved Domains (4) summary
    smart00228
    Location:23782460
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:8661231
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:7191024
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:260341
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_006520165.5XP_006520228.1  PDZ domain-containing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00228
    Location:26572739
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:11451510
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:9981303
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:539620
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_006520160.5XP_006520223.1  PDZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006520223.1

    UniProtKB/TrEMBL
    E9Q1M1
    Conserved Domains (4) summary
    smart00228
    Location:27092791
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:11971562
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:10501355
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:591672
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. XM_006520161.5XP_006520224.1  PDZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006520224.1

    UniProtKB/TrEMBL
    E9Q1M1
    Conserved Domains (4) summary
    smart00228
    Location:27092791
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:11971562
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:10501355
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:591672
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  8. XM_006520164.3XP_006520227.1  PDZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006520227.1

    UniProtKB/TrEMBL
    E9Q1M1
    Related
    ENSMUSP00000074788.6, ENSMUST00000075317.12
    Conserved Domains (4) summary
    smart00228
    Location:27092791
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:11971562
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:10501355
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:591672
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  9. XM_036159557.1XP_036015450.1  PDZ domain-containing protein 2 isoform X7

    Conserved Domains (4) summary
    smart00228
    Location:23782460
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:8661231
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:7191024
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:260341
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  10. XM_006520168.5XP_006520231.1  PDZ domain-containing protein 2 isoform X5

    See identical proteins and their annotated locations for XP_006520231.1

    Conserved Domains (4) summary
    smart00228
    Location:25352617
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:10231388
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:8761181
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:417498
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  11. XM_030248720.2XP_030104580.1  PDZ domain-containing protein 2 isoform X6

    Conserved Domains (4) summary
    smart00228
    Location:23912473
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:8791244
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:7321037
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:273354
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  12. XM_030248721.2XP_030104581.1  PDZ domain-containing protein 2 isoform X7

    Conserved Domains (4) summary
    smart00228
    Location:23782460
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:8661231
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:7191024
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:260341
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  13. XM_006520169.5XP_006520232.1  PDZ domain-containing protein 2 isoform X5

    See identical proteins and their annotated locations for XP_006520232.1

    Conserved Domains (4) summary
    smart00228
    Location:25352617
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:10231388
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:8761181
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:417498
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  14. XM_030248722.2XP_030104582.1  PDZ domain-containing protein 2 isoform X7

    Conserved Domains (4) summary
    smart00228
    Location:23782460
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:8661231
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:7191024
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:260341
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  15. XM_017316734.3XP_017172223.1  PDZ domain-containing protein 2 isoform X5

    Conserved Domains (4) summary
    smart00228
    Location:25352617
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:10231388
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:8761181
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:417498
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  16. XM_036159558.1XP_036015451.1  PDZ domain-containing protein 2 isoform X8

    UniProtKB/TrEMBL
    Q80U45
    Conserved Domains (2) summary
    smart00228
    Location:14311513
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:13031385
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. XR_004938867.1 RNA Sequence