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Nutf2 nuclear transport factor 2 [ Mus musculus (house mouse) ]

Gene ID: 68051, updated on 30-Apr-2024

Summary

Official Symbol
Nutf2provided by MGI
Official Full Name
nuclear transport factor 2provided by MGI
Primary source
MGI:MGI:1915301
See related
Ensembl:ENSMUSG00000008450 AllianceGenome:MGI:1915301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ntf2; Ntf3; PP15; 2700067I02Rik
Summary
Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within protein import into nucleus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nuclear pore central transport channel. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 42.8), CNS E14 (RPKM 34.0) and 28 other tissues See more
Orthologs
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Genomic context

See Nutf2 in Genome Data Viewer
Location:
8 D3; 8 53.05 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106587165..106607034)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105860533..105880402)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene translin-associated factor X (Tsnax) interacting protein 1 Neighboring gene centromere protein T Neighboring gene STARR-positive B cell enhancer ABC_E2875 Neighboring gene STARR-positive B cell enhancer ABC_E3799 Neighboring gene THAP domain containing 11 Neighboring gene STARR-seq mESC enhancer starr_22544 Neighboring gene STARR-seq mESC enhancer starr_22545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108404648-108404831 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene neuritin 1-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102015

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear import signal receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleocytoplasmic carrier activity IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear pore central transport channel ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357229.1NP_001344158.1  nuclear transport factor 2

    Status: VALIDATED

    Source sequence(s)
    AC116569, AC159265
    Consensus CDS
    CCDS22617.1
    UniProtKB/Swiss-Prot
    P61971, Q3TI35
    UniProtKB/TrEMBL
    Q3U8H8
    Conserved Domains (1) summary
    cd00780
    Location:7122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
  2. NM_001357230.1NP_001344159.1  nuclear transport factor 2

    Status: VALIDATED

    Source sequence(s)
    AC116569, AC159265
    Consensus CDS
    CCDS22617.1
    UniProtKB/Swiss-Prot
    P61971, Q3TI35
    UniProtKB/TrEMBL
    Q3U8H8
    Related
    ENSMUSP00000148713.2, ENSMUST00000212042.2
    Conserved Domains (1) summary
    cd00780
    Location:7122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
  3. NM_026532.4NP_080808.1  nuclear transport factor 2

    See identical proteins and their annotated locations for NP_080808.1

    Status: VALIDATED

    Source sequence(s)
    AK002461, BC086773, CJ059612
    Consensus CDS
    CCDS22617.1
    UniProtKB/Swiss-Prot
    P61971, Q3TI35
    UniProtKB/TrEMBL
    Q3U8H8
    Related
    ENSMUSP00000008594.8, ENSMUST00000008594.9
    Conserved Domains (1) summary
    cd00780
    Location:7122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106587165..106607034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)