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NUTF2 nuclear transport factor 2 [ Homo sapiens (human) ]

Gene ID: 10204, updated on 7-Jun-2020

Summary

Official Symbol
NUTF2provided by HGNC
Official Full Name
nuclear transport factor 2provided by HGNC
Primary source
HGNC:HGNC:13722
See related
Ensembl:ENSG00000102898 MIM:605813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTF2; PP15; NTF-2
Summary
This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in placenta (RPKM 14.8), testis (RPKM 14.7) and 25 other tissues See more
Orthologs

Genomic context

See NUTF2 in Genome Data Viewer
Location:
16q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67846933..67872567)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67880819..67906470)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene translin associated factor X interacting protein 1 Neighboring gene centromere protein T Neighboring gene THAP domain containing 11 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene neuritin 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Common variants at 30 loci contribute to polygenic dyslipidemia.
NHGRI GWA Catalog
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol NTF2 is enriched at the nuclear envelope and interacts with NUP153, When added in excess to the import assay, NUP153C inhibited the nuclear import of IN. PubMed
matrix gag NTF2 coordinates the activity of Ran by binding Ran-GDP into a complex with nucleoporin-docked karyopherins during nuclear import of HIV-1 Matrix PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ran GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Ran GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
nucleocytoplasmic transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear transport factor 2
Names
placental protein 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322038.2NP_001308967.1  nuclear transport factor 2

    Status: REVIEWED

    Source sequence(s)
    AC040162
    Consensus CDS
    CCDS10848.1
    UniProtKB/Swiss-Prot
    P61970
    UniProtKB/TrEMBL
    A0A024R6Y2
    Conserved Domains (1) summary
    cd00780
    Location:7122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
  2. NM_001322039.2NP_001308968.1  nuclear transport factor 2

    Status: REVIEWED

    Source sequence(s)
    AC040162, BP216441
    Consensus CDS
    CCDS10848.1
    UniProtKB/Swiss-Prot
    P61970
    UniProtKB/TrEMBL
    A0A024R6Y2
    Related
    ENSP00000456428.1, ENST00000567105.5
    Conserved Domains (1) summary
    cd00780
    Location:7122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
  3. NM_001322040.2NP_001308969.1  nuclear transport factor 2

    Status: REVIEWED

    Source sequence(s)
    BX647782, HY123109, X07315
    Consensus CDS
    CCDS10848.1
    UniProtKB/Swiss-Prot
    P61970
    UniProtKB/TrEMBL
    A0A024R6Y2
    Related
    ENSP00000457989.1, ENST00000569436.6
    Conserved Domains (1) summary
    cd00780
    Location:7122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
  4. NM_001322041.2NP_001308970.1  nuclear transport factor 2

    Status: REVIEWED

    Source sequence(s)
    AC040162, BX394845
    Consensus CDS
    CCDS10848.1
    UniProtKB/Swiss-Prot
    P61970
    UniProtKB/TrEMBL
    A0A024R6Y2
    Related
    ENSP00000457022.1, ENST00000568396.2
    Conserved Domains (1) summary
    cd00780
    Location:7122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
  5. NM_005796.3NP_005787.1  nuclear transport factor 2

    See identical proteins and their annotated locations for NP_005787.1

    Status: REVIEWED

    Source sequence(s)
    BX647782, X07315
    Consensus CDS
    CCDS10848.1
    UniProtKB/Swiss-Prot
    P61970
    UniProtKB/TrEMBL
    A0A024R6Y2
    Related
    ENSP00000219169.4, ENST00000219169.9
    Conserved Domains (1) summary
    cd00780
    Location:7122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67846933..67872567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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