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Chac2 ChaC, cation transport regulator 2 [ Mus musculus (house mouse) ]

Gene ID: 68044, updated on 11-Apr-2024

Summary

Official Symbol
Chac2provided by MGI
Official Full Name
ChaC, cation transport regulator 2provided by MGI
Primary source
MGI:MGI:1915294
See related
Ensembl:ENSMUSG00000020309 AllianceGenome:MGI:1915294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable gamma-glutamylcyclotransferase activity. Predicted to be involved in glutathione catabolic process. Predicted to be active in cytoplasm. Orthologous to human CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 15.9), liver E14.5 (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

See Chac2 in Genome Data Viewer
Location:
11 A4; 11 18.2 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (30926707..30936365, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30976707..30986365, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene G protein-coupled receptor 75 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene ankyrin repeat and SOCS box-containing 3 Neighboring gene GPN-loop GTPase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29073 Neighboring gene STARR-seq mESC enhancer starr_29074 Neighboring gene STARR-seq mESC enhancer starr_29075 Neighboring gene STARR-seq mESC enhancer starr_29076 Neighboring gene predicted gene, 40822

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Clone Names

  • 2510006C20Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione specific gamma-glutamylcyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione specific gamma-glutamylcyclotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
putative glutathione-specific gamma-glutamylcyclotransferase 2
Names
ChaC, cation transport regulator homolog 2
cation transport regulator-like protein 2
gamma-GCG 2
NP_001277596.1
NP_080803.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290667.1NP_001277596.1  putative glutathione-specific gamma-glutamylcyclotransferase 2 isoform 2

    See identical proteins and their annotated locations for NP_001277596.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK010914, AK021391, AL662891, BY333527
    Consensus CDS
    CCDS70154.1
    UniProtKB/Swiss-Prot
    Q9CQG1
    Related
    ENSMUSP00000020553.5, ENSMUST00000020553.5
    Conserved Domains (1) summary
    pfam04752
    Location:1162
    ChaC; ChaC-like protein
  2. NM_026527.3NP_080803.1  putative glutathione-specific gamma-glutamylcyclotransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_080803.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK078993, AL662891, BY333527
    Consensus CDS
    CCDS24510.1
    UniProtKB/Swiss-Prot
    Q8R3K5, Q9CQG1, Q9D1T7
    Related
    ENSMUSP00000098942.5, ENSMUST00000101394.5
    Conserved Domains (1) summary
    pfam04752
    Location:1174
    ChaC; ChaC-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    30926707..30936365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)