Format

Send to:

Choose Destination

CHAC2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 [ Homo sapiens (human) ]

Gene ID: 494143, updated on 24-Nov-2020

Summary

Official Symbol
CHAC2provided by HGNC
Official Full Name
ChaC glutathione specific gamma-glutamylcyclotransferase 2provided by HGNC
Primary source
HGNC:HGNC:32363
See related
Ensembl:ENSG00000143942 MIM:617446
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCG1
Summary
The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in duodenum (RPKM 3.6), testis (RPKM 3.6) and 25 other tissues See more
Orthologs

Genomic context

See CHAC2 in Genome Data Viewer
Location:
2p16.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (53767783..53775196)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (53994929..54002320)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374600 Neighboring gene uncharacterized LOC105374601 Neighboring gene GPR75-ASB3 readthrough Neighboring gene ankyrin repeat and SOCS box containing 3 Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene uncharacterized LOC112268415 Neighboring gene microRNA 3682

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
gamma-glutamylcyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione specific gamma-glutamylcyclotransferase activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
glutathione biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glutathione-specific gamma-glutamylcyclotransferase 2
Names
ChaC cation transport regulator homolog 2
ChaC, cation transport regulator-like 2
cation transport regulator-like protein 2
gamma-GCG 2
gamma-GCT acting on glutathione homolog 2
putative glutathione-specific gamma-glutamylcyclotransferase 2
NP_001008708.1
NP_001333056.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008708.4NP_001008708.1  glutathione-specific gamma-glutamylcyclotransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_001008708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC019239, BC053896
    Consensus CDS
    CCDS33196.1
    UniProtKB/Swiss-Prot
    Q8WUX2
    Related
    ENSP00000295304.4, ENST00000295304.5
    Conserved Domains (1) summary
    pfam04752
    Location:1174
    ChaC; ChaC-like protein
  2. NM_001346127.1NP_001333056.1  glutathione-specific gamma-glutamylcyclotransferase 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA465572, BC019239, BC053896, HY170056
    UniProtKB/Swiss-Prot
    Q8WUX2
    Conserved Domains (1) summary
    cl22886
    Location:2118
    GGCT_like; GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    53767783..53775196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center