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Srsf6 serine and arginine-rich splicing factor 6 [ Mus musculus (house mouse) ]

Gene ID: 67996, updated on 18-Dec-2022

Summary

Official Symbol
Srsf6provided by MGI
Official Full Name
serine and arginine-rich splicing factor 6provided by MGI
Primary source
MGI:MGI:1915246
See related
Ensembl:ENSMUSG00000016921 AllianceGenome:MGI:1915246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sfrs6; 1210001E11Rik
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in adrenal adult (RPKM 167.2), CNS E11.5 (RPKM 118.4) and 28 other tissues See more
Orthologs
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Genomic context

See Srsf6 in Genome Data Viewer
Location:
2 H2; 2 83.87 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162773428..162779041)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (162931508..162937121)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transcriptional adaptor 3 pseudogene Neighboring gene CDGSH iron sulfur domain 3B Neighboring gene L3MBTL1 histone methyl-lysine binding protein Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splice site selection ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/arginine-rich splicing factor 6
Names
pre-mRNA-splicing factor SRP55
splicing factor, arginine/serine-rich 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026499.4NP_080775.3  serine/arginine-rich splicing factor 6

    See identical proteins and their annotated locations for NP_080775.3

    Status: REVIEWED

    Source sequence(s)
    AK133872, AL590418, AL606473, BY783855
    Consensus CDS
    CCDS17002.1
    UniProtKB/Swiss-Prot
    Q3TWW8, Q9DBP1
    UniProtKB/TrEMBL
    A0A8C6IBL1
    Related
    ENSMUSP00000119065.2, ENSMUST00000130411.7
    Conserved Domains (2) summary
    cd12766
    Location:110182
    RRM2_SRSF6; RNA recognition motif 2 (RRM2) found found in vertebrate serine/arginine-rich splicing factor 6 (SRSF6)
    cl17169
    Location:172
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    162773428..162779041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)