Format

Send to:

Choose Destination

AURKC aurora kinase C [ Homo sapiens (human) ]

Gene ID: 6795, updated on 17-Jun-2019

Summary

Official Symbol
AURKCprovided by HGNC
Official Full Name
aurora kinase Cprovided by HGNC
Primary source
HGNC:HGNC:11391
See related
Ensembl:ENSG00000105146 MIM:603495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C
Summary
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 14.8), brain (RPKM 1.0) and 1 other tissue See more
Orthologs

Genomic context

See AURKC in Genome Data Viewer
Location:
19q13.43
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57230317..57235550)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57741750..57746916)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pentatricopeptide repeat domain 3 pseudogene Neighboring gene zinc finger protein 264 Neighboring gene Sharpr-MPRA regulatory region 2652 Neighboring gene zinc finger protein 805 Neighboring gene ZNF460 antisense RNA 1 Neighboring gene zinc finger protein 460

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
histone serine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
attachment of spindle microtubules to kinetochore TAS
Traceable Author Statement
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
histone modification TAS
Traceable Author Statement
more info
PubMed 
histone-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle midzone assembly TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oocyte development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokinesis TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome passenger complex TAS
Traceable Author Statement
more info
PubMed 
condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
condensed nuclear chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
midbody TAS
Traceable Author Statement
more info
PubMed 
spindle TAS
Traceable Author Statement
more info
PubMed 
spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
aurora kinase C
Names
ARK-3
aurora 3
aurora-related kinase 3
aurora/IPL1-related kinase 3
aurora/IPL1/EG2 protein 2
epididymis secretory protein Li 90
serine/threonine kinase 13 (aurora/IPL1-like)
serine/threonine-protein kinase 13
serine/threonine-protein kinase aurora-C
NP_001015878.1
NP_001015879.1
NP_003151.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012134.1 RefSeqGene

    Range
    5001..9540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015878.2NP_001015878.1  aurora kinase C isoform 1

    See identical proteins and their annotated locations for NP_001015878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC005261, AF054621, AY661554
    Consensus CDS
    CCDS33128.1
    UniProtKB/Swiss-Prot
    Q9UQB9
    Related
    ENSP00000302898.6, ENST00000302804.11
    Conserved Domains (2) summary
    smart00220
    Location:43293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14117
    Location:36305
    STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins
  2. NM_001015879.2NP_001015879.1  aurora kinase C isoform 2

    See identical proteins and their annotated locations for NP_001015879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as Aurora C-SV, uses an alternate splice site at the 5' end of the first intron and an alternate upstream translation initiation site, compared to variant 1. The encoded protein (isoform 2) contains a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB017332, AY661554, BX092186
    Consensus CDS
    CCDS46205.1
    UniProtKB/Swiss-Prot
    Q9UQB9
    Related
    ENSP00000407162.1, ENST00000415300.6
    Conserved Domains (2) summary
    smart00220
    Location:24274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14117
    Location:17286
    STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins
  3. NM_003160.3NP_003151.2  aurora kinase C isoform 3

    See identical proteins and their annotated locations for NP_003151.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at the 5' end of the first intron and an alternate downstream translation initiation site, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB017332, AF054621, AF059681, AY661554
    Consensus CDS
    CCDS46206.1
    UniProtKB/Swiss-Prot
    Q9UQB9
    Related
    ENSP00000471830.1, ENST00000598785.5
    Conserved Domains (1) summary
    cl21453
    Location:2271
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57230317..57235550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_430209.3 RNA Sequence

Support Center