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AURKC aurora kinase C [ Homo sapiens (human) ]

Gene ID: 6795, updated on 28-Nov-2021

Summary

Official Symbol
AURKCprovided by HGNC
Official Full Name
aurora kinase Cprovided by HGNC
Primary source
HGNC:HGNC:11391
See related
Ensembl:ENSG00000105146 MIM:603495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C
Summary
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 14.8), brain (RPKM 1.0) and 1 other tissue See more
Orthologs
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Genomic context

See AURKC in Genome Data Viewer
Location:
19q13.43
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57230317..57235550)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57742391..57746916)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pentatricopeptide repeat domain 3 pseudogene Neighboring gene zinc finger protein 264 Neighboring gene Sharpr-MPRA regulatory region 2652 Neighboring gene zinc finger protein 805 Neighboring gene ZNF460 antisense RNA 1 Neighboring gene zinc finger protein 460

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables histone serine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore TAS
Traceable Author Statement
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in histone modification TAS
Traceable Author Statement
more info
PubMed 
involved_in histone-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic spindle midzone assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokinesis TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of chromosome passenger complex TAS
Traceable Author Statement
more info
PubMed 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in spindle TAS
Traceable Author Statement
more info
PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
aurora kinase C
Names
ARK-3
aurora 3
aurora-related kinase 3
aurora/IPL1-related kinase 3
aurora/IPL1/EG2 protein 2
epididymis secretory protein Li 90
serine/threonine kinase 13 (aurora/IPL1-like)
serine/threonine-protein kinase 13
serine/threonine-protein kinase aurora-C
NP_001015878.1
NP_001015879.1
NP_003151.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012134.1 RefSeqGene

    Range
    5015..9540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015878.2NP_001015878.1  aurora kinase C isoform 1

    See identical proteins and their annotated locations for NP_001015878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC005261, AF054621, AY661554
    Consensus CDS
    CCDS33128.1
    UniProtKB/Swiss-Prot
    Q9UQB9
    Related
    ENSP00000302898.6, ENST00000302804.12
    Conserved Domains (2) summary
    smart00220
    Location:43293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14117
    Location:36305
    STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins
  2. NM_001015879.2NP_001015879.1  aurora kinase C isoform 2

    See identical proteins and their annotated locations for NP_001015879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as Aurora C-SV, uses an alternate splice site at the 5' end of the first intron and an alternate upstream translation initiation site, compared to variant 1. The encoded protein (isoform 2) contains a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB017332, AY661554, BX092186
    Consensus CDS
    CCDS46205.1
    UniProtKB/Swiss-Prot
    Q9UQB9
    Related
    ENSP00000407162.1, ENST00000415300.6
    Conserved Domains (2) summary
    smart00220
    Location:24274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14117
    Location:17286
    STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins
  3. NM_003160.3NP_003151.2  aurora kinase C isoform 3

    See identical proteins and their annotated locations for NP_003151.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at the 5' end of the first intron and an alternate downstream translation initiation site, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB017332, AF054621, AF059681, AY661554
    Consensus CDS
    CCDS46206.1
    UniProtKB/Swiss-Prot
    Q9UQB9
    Related
    ENSP00000471830.1, ENST00000598785.5
    Conserved Domains (1) summary
    cl21453
    Location:2271
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57230317..57235550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_430209.3 RNA Sequence

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