Rps27l ribosomal protein S27-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps27lprovided by MGI
Official Full Name: ribosomal protein S27-likeprovided by MGI
Primary source: MGI:MGI:1915191
See related: Ensembl:ENSMUSG00000036781 AllianceGenome:MGI:1915191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810034D23Rik
Summary: Predicted to enable RNA binding activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and translation activator activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in intracellular signal transduction; positive regulation of protein metabolic process; and ribosomal small subunit assembly. Predicted to be located in nucleus. Predicted to be part of cytosolic small ribosomal subunit. Is expressed in several structures, including alimentary system; lung; nose; skeletal musculature; and ventricular layer. Orthologous to human RPS27L (ribosomal protein S27 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in placenta adult (RPKM 58.6), liver E14 (RPKM 50.1) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 36.23 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (66851906..66856804)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (66944624..66949522)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study revealed a physiological condition under which Rps27l regulates the Mdm2/p53 and MRN/Atm axes to maintain DNA damage response and to confer radioprotection in vivo.
Title: Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes.
Data suggest that ribosomal protein S27-like (Rps27l) is an essential gene for postnatal development by modulating tumor suppressor protein p53.
Title: Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables translation activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in mitotic G1 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small ribosomal subunit protein eS27-like

Names: 40S ribosomal protein S27-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311101.2 → NP_001298030.1 small ribosomal subunit protein eS27-like isoform 1

See identical proteins and their annotated locations for NP_001298030.1

Status: VALIDATED

Source sequence(s)

AC159741, AV040832, BE133731, BY088997

Consensus CDS

CCDS81028.1

UniProtKB/TrEMBL

D3YYB0

Related

ENSMUSP00000120518.2, ENSMUST00000127896.8

Conserved Domains (1) summary

cl00897
Location:6 → 80

Ribosomal_S27e; Ribosomal protein S27
NM_001361106.1 → NP_001348035.1 small ribosomal subunit protein eS27-like isoform 3

Status: VALIDATED

Source sequence(s)

AC159741

UniProtKB/TrEMBL

A0A0G2JDW7

Related

ENSMUST00000143044.2

Conserved Domains (1) summary

PLN00209
Location:20 → 96

PLN00209; ribosomal protein S27; Provisional
NM_026467.5 → NP_080743.1 small ribosomal subunit protein eS27-like isoform 2

See identical proteins and their annotated locations for NP_080743.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region that results in a frame-shift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC159741, AK007689, AV040832, BY088997

Consensus CDS

CCDS40673.1

UniProtKB/Swiss-Prot

Q3UB68, Q6ZWY3

UniProtKB/TrEMBL

A0A0G2JDW7

Related

ENSMUSP00000046016.8, ENSMUST00000040917.14

Conserved Domains (1) summary

PLN00209
Location:6 → 82

PLN00209; ribosomal protein S27; Provisional

RNA

NR_154464.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC159741

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

66851906..66856804

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313541.2 → XP_017169030.1 small ribosomal subunit protein eS27-like isoform X1

Conserved Domains (1) summary

cl00897
Location:6 → 80

Ribosomal_S27e; Ribosomal protein S27