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STK11 serine/threonine kinase 11 [ Homo sapiens (human) ]

Gene ID: 6794, updated on 2-Aug-2020

Summary

Official Symbol
STK11provided by HGNC
Official Full Name
serine/threonine kinase 11provided by HGNC
Primary source
HGNC:HGNC:11389
See related
Ensembl:ENSG00000118046 MIM:602216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PJS; LKB1; hLKB1
Summary
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 28.3), spleen (RPKM 10.4) and 25 other tissues See more
Orthologs

Genomic context

See STK11 in Genome Data Viewer
Location:
19p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (1205778..1228431)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1205798..1228434)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 734 Neighboring gene high mobility group box 2 pseudogene 1 Neighboring gene serine/threonine kinase 11 intron 1 Alu-mediated recombination region Neighboring gene serine/threonine kinase 11 intron 3 Alu-mediated recombination region Neighboring gene CACN subunit beta associated regulatory protein Neighboring gene ATP synthase F1 subunit delta Neighboring gene uncharacterized LOC102723811

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in STK11 that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Associated conditions

Description Tests
Carcinoma of pancreas
MedGen: C0235974 OMIM: 260350 GeneReviews: Not available
Compare labs
Malignant tumor of testis
MedGen: C0153594 OMIM: 273300 GeneReviews: Not available
Compare labs
Peutz-Jeghers syndrome
MedGen: C0031269 OMIM: 175200 GeneReviews: Peutz-Jeghers Syndrome
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2015-11-20)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2015-11-20)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
LRR domain binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
p53 binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
Golgi localization IEA
Inferred from Electronic Annotation
more info
 
T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy IEA
Inferred from Electronic Annotation
more info
 
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest TAS
Traceable Author Statement
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to UV-B IDA
Inferred from Direct Assay
more info
PubMed 
dendrite extension IEA
Inferred from Electronic Annotation
more info
 
establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
intrinsic apoptotic signaling pathway by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of epithelial cell proliferation involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
tissue homeostasis IEA
Inferred from Electronic Annotation
more info
 
vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase STK11
Names
liver kinase B1
polarization-related protein LKB1
renal carcinoma antigen NY-REN-19
serine/threonine-protein kinase 11
serine/threonine-protein kinase LKB1
NP_000446.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007460.2 RefSeqGene

    Range
    21393..44029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_319

mRNA and Protein(s)

  1. NM_000455.5NP_000446.1  serine/threonine-protein kinase STK11

    See identical proteins and their annotated locations for NP_000446.1

    Status: REVIEWED

    Source sequence(s)
    AC011544, BC007981, BC019334, BM993274, BQ222023, BU174122, BU739451
    Consensus CDS
    CCDS45896.1
    UniProtKB/Swiss-Prot
    Q15831
    UniProtKB/TrEMBL
    A0A0S2Z4D1
    Related
    ENSP00000324856.6, ENST00000326873.12
    Conserved Domains (1) summary
    cd14119
    Location:55309
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    1205778..1228431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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