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Dennd10 DENN domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 67894, updated on 2-Nov-2024

Summary

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Official Symbol
Dennd10provided by MGI
Official Full Name
DENN domain containing 10provided by MGI
Primary source
MGI:MGI:1915144
See related
Ensembl:ENSMUSG00000024993 AllianceGenome:MGI:1915144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam45a; 1810055E12Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in endosome transport via multivesicular body sorting pathway; protein transport; and regulation of early endosome to late endosome transport. Predicted to be active in late endosome. Orthologous to several human genes including DENND10 (DENN domain containing 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 13.5), placenta adult (RPKM 12.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Dennd10 in Genome Data Viewer
Location:
19 D3; 19 56.52 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60800029..60824673)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60811555..60836235)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11044 Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene eukaryotic translation initiation factor 3, subunit A Neighboring gene microRNA 3084-2 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene STARR-positive B cell enhancer ABC_E7677 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60887142-60887443 Neighboring gene 60S ribosomal protein L26-like Neighboring gene sideroflexin 4 Neighboring gene STARR-positive B cell enhancer ABC_E7678 Neighboring gene peroxiredoxin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endosome transport via multivesicular body sorting pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of early endosome to late endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of early endosome to late endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 10
Names
family with sequence similarity 45, member A
protein FAM45A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167829.3 → NP_001161301.1  DENN domain-containing protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163019
    UniProtKB/Swiss-Prot
    Q9D8N2
    Conserved Domains (1) summary
    pfam09794
    Location:139 → 241
    Avl9; Transport protein Avl9

  2. NM_001347464.2 → NP_001334393.1  DENN domain-containing protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163019
    Consensus CDS
    CCDS84460.1
    UniProtKB/TrEMBL
    Q3TH34
    Conserved Domains (1) summary
    cl40631
    Location:37 → 143
    SPA; Stabilization of polarity axis

  3. NM_001360619.2 → NP_001347548.1  DENN domain-containing protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163019
    Consensus CDS
    CCDS84460.1
    UniProtKB/TrEMBL
    Q3TH34
    Related
    ENSMUSP00000112839.2, ENSMUST00000119633.8
    Conserved Domains (1) summary
    cl40631
    Location:37 → 143
    SPA; Stabilization of polarity axis

  4. NM_001360620.2 → NP_001347549.2  DENN domain-containing protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163019
    UniProtKB/TrEMBL
    Q3TH34
    Conserved Domains (1) summary
    cl40631
    Location:37 → 143
    SPA; Stabilization of polarity axis

  5. NM_026437.5 → NP_080713.2  DENN domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_080713.2

    Status: VALIDATED

    Source sequence(s)
    AC163019
    Consensus CDS
    CCDS29942.1
    UniProtKB/Swiss-Prot
    Q3UL11, Q91WS5, Q9D8N2
    Related
    ENSMUSP00000025957.9, ENSMUST00000025957.9
    Conserved Domains (1) summary
    pfam08616
    Location:158 → 264
    SPA; Stabilization of polarity axis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    60800029..60824673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8N2.2 GenPept UniProtKB/Swiss-Prot:Q9D8N2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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