Format

Send to:

Choose Destination

DENND10 DENN domain containing 10 [ Homo sapiens (human) ]

Gene ID: 404636, updated on 4-Jun-2020

Summary

Official Symbol
DENND10provided by HGNC
Official Full Name
DENN domain containing 10provided by HGNC
Primary source
HGNC:HGNC:31793
See related
Ensembl:ENSG00000119979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM45A
Expression
Ubiquitous expression in thyroid (RPKM 10.5), esophagus (RPKM 8.9) and 25 other tissues See more
Orthologs

Genomic context

See DENND10 in Genome Data Viewer
Location:
10q26.11
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (119104082..119137984)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120863594..120897496)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit A Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene Sharpr-MPRA regulatory region 2008 Neighboring gene sideroflexin 4 Neighboring gene peroxiredoxin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ55853

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endosome transport via multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
late endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DENN domain-containing protein 10
Names
family with sequence similarity 45 member A
protein FAM45A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303111.2NP_001290040.1  DENN domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001290040.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon and uses an alternate splice site in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK293136, AL355598, BC022271, DA531569
    UniProtKB/Swiss-Prot
    Q8TCE6
    Conserved Domains (1) summary
    pfam08616
    Location:150256
    SPA; Stabilization of polarity axis
  2. NM_001303112.2NP_001290041.1  DENN domain-containing protein 10 isoform 3

    See identical proteins and their annotated locations for NP_001290041.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK297971, AL355598, BC022271, DA531569
    UniProtKB/Swiss-Prot
    Q8TCE6
    UniProtKB/TrEMBL
    B4DNL9
    Conserved Domains (1) summary
    pfam08616
    Location:85191
    SPA; Stabilization of polarity axis
  3. NM_001303113.2NP_001290042.1  DENN domain-containing protein 10 isoform 4

    See identical proteins and their annotated locations for NP_001290042.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks an exon in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK297633, AL355598, BC022271, DA531569
    UniProtKB/Swiss-Prot
    Q8TCE6
    UniProtKB/TrEMBL
    B4DMU4
    Conserved Domains (1) summary
    pfam08616
    Location:9113
    SPA; Stabilization of polarity axis
  4. NM_207009.4NP_996892.1  DENN domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_996892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL355598, BC022271, DA531569
    Consensus CDS
    CCDS7609.1
    UniProtKB/Swiss-Prot
    Q8TCE6
    Related
    ENSP00000354688.2, ENST00000361432.3
    Conserved Domains (1) summary
    pfam08616
    Location:158264
    SPA; Stabilization of polarity axis

RNA

  1. NR_130122.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK293365, AL355598, BC022271

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    119104082..119137984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016261.1XP_016871750.1  DENN domain-containing protein 10 isoform X1

    UniProtKB/Swiss-Prot
    Q8TCE6
    Conserved Domains (1) summary
    pfam08616
    Location:150256
    SPA; Stabilization of polarity axis
  2. XM_017016263.1XP_016871752.1  DENN domain-containing protein 10 isoform X1

    UniProtKB/Swiss-Prot
    Q8TCE6
    Conserved Domains (1) summary
    pfam08616
    Location:150256
    SPA; Stabilization of polarity axis
  3. XM_006717850.3XP_006717913.1  DENN domain-containing protein 10 isoform X3

    See identical proteins and their annotated locations for XP_006717913.1

    Conserved Domains (1) summary
    pfam08616
    Location:47153
    SPA; Stabilization of polarity axis
  4. XM_017016265.1XP_016871754.1  DENN domain-containing protein 10 isoform X3

    Conserved Domains (1) summary
    pfam08616
    Location:47153
    SPA; Stabilization of polarity axis
  5. XM_006717851.3XP_006717914.1  DENN domain-containing protein 10 isoform X3

    See identical proteins and their annotated locations for XP_006717914.1

    Conserved Domains (1) summary
    pfam08616
    Location:47153
    SPA; Stabilization of polarity axis
  6. XM_017016267.1XP_016871756.1  DENN domain-containing protein 10 isoform X3

    Related
    ENSP00000496780.1, ENST00000648560.1
    Conserved Domains (1) summary
    pfam08616
    Location:47153
    SPA; Stabilization of polarity axis
  7. XM_006717852.3XP_006717915.1  DENN domain-containing protein 10 isoform X3

    See identical proteins and their annotated locations for XP_006717915.1

    Conserved Domains (1) summary
    pfam08616
    Location:47153
    SPA; Stabilization of polarity axis
  8. XM_017016264.2XP_016871753.1  DENN domain-containing protein 10 isoform X2

  9. XM_006717849.4XP_006717912.1  DENN domain-containing protein 10 isoform X3

    See identical proteins and their annotated locations for XP_006717912.1

    Conserved Domains (1) summary
    pfam08616
    Location:47153
    SPA; Stabilization of polarity axis
  10. XM_017016262.2XP_016871751.1  DENN domain-containing protein 10 isoform X1

    UniProtKB/Swiss-Prot
    Q8TCE6
    Conserved Domains (1) summary
    pfam08616
    Location:150256
    SPA; Stabilization of polarity axis
  11. XM_017016266.2XP_016871755.1  DENN domain-containing protein 10 isoform X3

    Conserved Domains (1) summary
    pfam08616
    Location:47153
    SPA; Stabilization of polarity axis
Support Center