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Dcxr dicarbonyl L-xylulose reductase [ Mus musculus (house mouse) ]

Gene ID: 67880, updated on 26-Sep-2022

Summary

Official Symbol
Dcxrprovided by MGI
Official Full Name
dicarbonyl L-xylulose reductaseprovided by MGI
Primary source
MGI:MGI:1915130
See related
Ensembl:ENSMUSG00000039450 AllianceGenome:MGI:1915130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XR; 0610038K04Rik; 1810027P18Rik
Summary
Enables L-xylulose reductase (NADP+) activity. Involved in glucose metabolic process. Acts upstream of or within NADP metabolic process and xylulose metabolic process. Located in brush border and microvillus. Is expressed in adrenal gland; alimentary system; genitourinary system; respiratory system; and thymus. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 258.2), liver adult (RPKM 151.9) and 15 other tissues See more
Orthologs
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Genomic context

See Dcxr in Genome Data Viewer
Location:
11; 11 E2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120615372..120618110, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120724546..120727284, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 45 Neighboring gene Rac family small GTPase 3 Neighboring gene carbonyl reductase 2 Neighboring gene high mobility group AT-hook 1B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
L-xylulose reductase
Names
diacetyl/L-xylulose reductase
NP_001334537.1
NP_080704.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347608.1NP_001334537.1  L-xylulose reductase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663030
    Consensus CDS
    CCDS83949.1
    UniProtKB/TrEMBL
    A2AC16
    Related
    ENSMUSP00000101754.4, ENSMUST00000106148.10
  2. NM_026428.3NP_080704.2  L-xylulose reductase isoform 1

    See identical proteins and their annotated locations for NP_080704.2

    Status: VALIDATED

    Source sequence(s)
    AK007627, AK153521, AL663030, BY500715
    Consensus CDS
    CCDS25755.1
    UniProtKB/Swiss-Prot
    Q91X52, Q9D8W1
    UniProtKB/TrEMBL
    A0A8C6I2Q1
    Related
    ENSMUSP00000026144.5, ENSMUST00000026144.5
    Conserved Domains (2) summary
    PRK07060
    Location:6244
    PRK07060; short chain dehydrogenase; Provisional
    cd05351
    Location:1243
    XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120615372..120618110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)