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DCXR dicarbonyl and L-xylulose reductase [ Homo sapiens (human) ]

Gene ID: 51181, updated on 5-Aug-2018

Summary

Official Symbol
DCXRprovided by HGNC
Official Full Name
dicarbonyl and L-xylulose reductaseprovided by HGNC
Primary source
HGNC:HGNC:18985
See related
Ensembl:ENSG00000169738 MIM:608347; Vega:OTTHUMG00000178483
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XR; DCR; HCR2; P34H; HCRII; KIDCR; PNTSU; SDR20C1
Summary
The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Expression
Biased expression in liver (RPKM 345.1), kidney (RPKM 158.4) and 7 other tissues See more
Orthologs

Genomic context

See DCXR in Genome Data Viewer
Location:
17q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (82035881..82037697, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79993757..79995573, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 45 Neighboring gene Rac family small GTPase 3 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-xylulose reductase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
L-xylulose reductase (NADP+) activity EXP
Inferred from Experiment
more info
PubMed 
L-xylulose reductase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-xylulose reductase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
D-xylose metabolic process IEA
Inferred from Electronic Annotation
more info
 
NADP metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glucuronate catabolic process to xylulose 5-phosphate TAS
Traceable Author Statement
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
xylulose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xylulose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
brush border IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
microvillus IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
L-xylulose reductase
Names
carbonyl reductase 2
carbonyl reductase II
dicarbonyl/L-xylulose reductase
kidney dicarbonyl reductase
short chain dehydrogenase/reductase family 20C member 1
sperm surface protein P34H
NP_001182147.1
NP_057370.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027681.1 RefSeqGene

    Range
    5001..6817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195218.1NP_001182147.1  L-xylulose reductase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 2 aa shorter compared to isoform 1.
    Source sequence(s)
    AF113123, AV653537, BG434209
    UniProtKB/Swiss-Prot
    Q7Z4W1
    Related
    ENSP00000462272.1, OTTHUMP00000259531, ENST00000582900.5, OTTHUMT00000442158
    Conserved Domains (2) summary
    PRK07060
    Location:6241
    PRK07060; short chain dehydrogenase; Provisional
    cd05351
    Location:1242
    XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs
  2. NM_016286.3NP_057370.1  L-xylulose reductase isoform 1

    See identical proteins and their annotated locations for NP_057370.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF113123, BG434209
    Consensus CDS
    CCDS11799.1
    UniProtKB/Swiss-Prot
    Q7Z4W1
    Related
    ENSP00000303356.2, OTTHUMP00000259529, ENST00000306869.6, OTTHUMT00000442153
    Conserved Domains (1) summary
    cd05351
    Location:1244
    XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    82035881..82037697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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