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STK3 serine/threonine kinase 3 [ Homo sapiens (human) ]

Gene ID: 6788, updated on 23-Apr-2019

Summary

Official Symbol
STK3provided by HGNC
Official Full Name
serine/threonine kinase 3provided by HGNC
Primary source
HGNC:HGNC:11406
See related
Ensembl:ENSG00000104375 MIM:605030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRS1; MST2
Summary
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in endometrium (RPKM 3.0), placenta (RPKM 2.4) and 25 other tissues See more
Orthologs

Genomic context

See STK3 in Genome Data Viewer
Location:
8q22.2
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (98433048..98944329, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (99466859..99954799, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs908 Neighboring gene potassium voltage-gated channel modifier subfamily S member 2 Neighboring gene RNA, U6 small nuclear 748, pseudogene Neighboring gene ATP synthase-coupling factor 6, mitochondrial-like Neighboring gene ribosomal protein L19 pseudogene 14 Neighboring gene uncharacterized LOC112268016 Neighboring gene RNA binding motif protein 4B pseudogene Neighboring gene mitochondrial ribosomal protein L57 pseudogene 7 Neighboring gene RN7SK pseudogene 85 Neighboring gene uncharacterized LOC107986872 Neighboring gene odd-skipped related transciption factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Hippo signaling, organism-specific biosystem (from KEGG)
    Hippo signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling, conserved biosystem (from KEGG)
    Hippo signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway -multiple species, organism-specific biosystem (from KEGG)
    Hippo signaling pathway -multiple species, organism-specific biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • Hippo signaling pathway -multiple species, conserved biosystem (from KEGG)
    Hippo signaling pathway -multiple species, conserved biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Hippo, organism-specific biosystem (from REACTOME)
    Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90748

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
central nervous system development IEA
Inferred from Electronic Annotation
more info
 
endocardium development IEA
Inferred from Electronic Annotation
more info
 
hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
hippo signaling TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
neural tube formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
primitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 3
Names
KB-1458E12.1
MST-2
STE20-like kinase MST2
epididymis secretory sperm binding protein
mammalian STE20-like protein kinase 2
serine/threonine kinase 3 (STE20 homolog, yeast)
serine/threonine kinase 3 (Ste20, yeast homolog)
serine/threonine-protein kinase Krs-1
NP_001243241.1
NP_001243242.1
NP_006272.2
XP_011515550.2
XP_011515553.1
XP_011515554.2
XP_011515557.1
XP_011515559.2
XP_011515560.1
XP_016869245.1
XP_016869246.1
XP_016869247.1
XP_016869248.1
XP_016869249.1
XP_016869250.1
XP_016869251.1
XP_016869253.1
XP_024303006.1
XP_024303007.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256312.1NP_001243241.1  serine/threonine-protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001243241.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an alternate start codon compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AK131363, AP003355
    Consensus CDS
    CCDS59108.1
    UniProtKB/Swiss-Prot
    Q13188
    Related
    ENSP00000429744.1, ENST00000523601.5
    Conserved Domains (3) summary
    cd06612
    Location:51306
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:55306
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:465512
    Mst1_SARAH; C terminal SARAH domain of Mst1
  2. NM_001256313.1NP_001243242.1  serine/threonine-protein kinase 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AA370619, AK307787, AP002087, AP003355
    Consensus CDS
    CCDS75774.1
    UniProtKB/TrEMBL
    A0A087WZ06
    Related
    ENSP00000482260.1, ENST00000617590.1
    Conserved Domains (2) summary
    pfam11629
    Location:326373
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:23167
    PKc_like; Protein Kinases, catalytic domain
  3. NM_006281.4NP_006272.2  serine/threonine-protein kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_006272.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AP003551, BC010640, U26424
    Consensus CDS
    CCDS47900.1
    UniProtKB/Swiss-Prot
    Q13188
    Related
    ENSP00000390500.2, ENST00000419617.7
    Conserved Domains (2) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    pfam11629
    Location:437484
    Mst1_SARAH; C terminal SARAH domain of Mst1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    98433048..98944329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447238.1XP_024303006.1  serine/threonine-protein kinase 3 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:15182
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017013759.2XP_016869248.1  serine/threonine-protein kinase 3 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:15182
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011517251.2XP_011515553.1  serine/threonine-protein kinase 3 isoform X4

    Conserved Domains (2) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:27278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. XM_017013760.2XP_016869249.1  serine/threonine-protein kinase 3 isoform X8

  5. XM_017013764.2XP_016869253.1  serine/threonine-protein kinase 3 isoform X14

    Conserved Domains (1) summary
    cl21453
    Location:147
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011517258.2XP_011515560.1  serine/threonine-protein kinase 3 isoform X14

    Conserved Domains (1) summary
    cl21453
    Location:147
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011517255.3XP_011515557.1  serine/threonine-protein kinase 3 isoform X10

    Conserved Domains (1) summary
    cl21453
    Location:74123
    PKc_like; Protein Kinases, catalytic domain
  8. XM_017013756.1XP_016869245.1  serine/threonine-protein kinase 3 isoform X1

  9. XM_011517248.2XP_011515550.2  serine/threonine-protein kinase 3 isoform X2

  10. XM_017013758.1XP_016869247.1  serine/threonine-protein kinase 3 isoform X6

  11. XM_017013761.2XP_016869250.1  serine/threonine-protein kinase 3 isoform X9

  12. XM_024447239.1XP_024303007.1  serine/threonine-protein kinase 3 isoform X11

    Conserved Domains (2) summary
    pfam11629
    Location:282329
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:74123
    PKc_like; Protein Kinases, catalytic domain
  13. XM_011517252.3XP_011515554.2  serine/threonine-protein kinase 3 isoform X5

  14. XM_017013757.1XP_016869246.1  serine/threonine-protein kinase 3 isoform X3

  15. XM_011517257.2XP_011515559.2  serine/threonine-protein kinase 3 isoform X12

  16. XM_017013762.2XP_016869251.1  serine/threonine-protein kinase 3 isoform X13

RNA

  1. XR_001745584.1 RNA Sequence

  2. XR_001745585.1 RNA Sequence

  3. XR_001745586.1 RNA Sequence

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