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STK3 serine/threonine kinase 3 [ Homo sapiens (human) ]

Gene ID: 6788, updated on 4-Feb-2024

Summary

Official Symbol
STK3provided by HGNC
Official Full Name
serine/threonine kinase 3provided by HGNC
Primary source
HGNC:HGNC:11406
See related
Ensembl:ENSG00000104375 MIM:605030; AllianceGenome:HGNC:11406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRS1; MST2
Summary
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in endometrium (RPKM 3.0), placenta (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

See STK3 in Genome Data Viewer
Location:
8q22.2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (98343975..98942610, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (99469462..100069002, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (99466861..99954838, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NIPAL2 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 914, pseudogene Neighboring gene NIPA like domain containing 2 Neighboring gene uncharacterized LOC105375659 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:99271842-99273041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19396 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:99317371-99318570 Neighboring gene NANOG hESC enhancer GRCh37_chr8:99355446-99355947 Neighboring gene Sharpr-MPRA regulatory region 13929 Neighboring gene uncharacterized LOC124901988 Neighboring gene Sharpr-MPRA regulatory region 12621 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:99396932-99397599 Neighboring gene WASH complex subunit 3 pseudogene Neighboring gene VISTA enhancer hs908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99434278-99434886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19397 Neighboring gene microRNA 9903 Neighboring gene RNA, U6 small nuclear 748, pseudogene Neighboring gene potassium voltage-gated channel modifier subfamily S member 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:99601941-99603140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27679 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:99662307-99662918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:99662919-99663529 Neighboring gene ATP5PF pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99751213-99751712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27680 Neighboring gene Sharpr-MPRA regulatory region 12470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19398 Neighboring gene ribosomal protein L19 pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99854811-99855310 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:99863496-99863646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99902922-99903422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:99924603-99925102 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:99924101-99924602 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene RNA binding motif protein 4B pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99956934-99957434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99957435-99957935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99959518-99960123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27681 Neighboring gene mitochondrial ribosomal protein L57 pseudogene 7 Neighboring gene uncharacterized LOC107986872 Neighboring gene MPRA-validated peak7120 silencer Neighboring gene RN7SK pseudogene 85 Neighboring gene odd-skipped related transciption factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ90748

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in endocardium development IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
involved_in hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hippo signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
involved_in neural tube formation IEA
Inferred from Electronic Annotation
more info
 
involved_in organ growth IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in primitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to centrosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 3
Names
KB-1458E12.1
MST-2
STE20-like kinase MST2
epididymis secretory sperm binding protein
hippo homolog
mammalian STE20-like protein kinase 2
serine/threonine kinase 3 (STE20 homolog, yeast)
serine/threonine kinase 3 (Ste20, yeast homolog)
serine/threonine-protein kinase Krs-1
NP_001243241.1
NP_001243242.1
NP_006272.2
XP_011515550.2
XP_011515553.1
XP_011515554.2
XP_011515559.2
XP_016869245.1
XP_016869246.1
XP_016869247.1
XP_016869250.1
XP_047278088.1
XP_047278089.1
XP_047278090.1
XP_047278091.1
XP_047278092.1
XP_047278093.1
XP_054217046.1
XP_054217047.1
XP_054217048.1
XP_054217049.1
XP_054217050.1
XP_054217051.1
XP_054217052.1
XP_054217053.1
XP_054217054.1
XP_054217055.1
XP_054217056.1
XP_054217057.1
XP_054217058.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256312.2NP_001243241.1  serine/threonine-protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001243241.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an alternate start codon compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AC016877, AK131363, AP003355
    Consensus CDS
    CCDS59108.1
    UniProtKB/Swiss-Prot
    Q13188
    Related
    ENSP00000429744.1, ENST00000523601.5
    Conserved Domains (3) summary
    cd06612
    Location:51306
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:55306
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:465512
    Mst1_SARAH; C terminal SARAH domain of Mst1
  2. NM_001256313.2NP_001243242.1  serine/threonine-protein kinase 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AA370619, AK307787, AP002087, AP003355, AP003551
    Consensus CDS
    CCDS75774.1
    UniProtKB/TrEMBL
    A0A087WZ06
    Related
    ENSP00000482260.1, ENST00000617590.1
    Conserved Domains (2) summary
    pfam11629
    Location:326373
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:23167
    PKc_like; Protein Kinases, catalytic domain
  3. NM_006281.4NP_006272.2  serine/threonine-protein kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_006272.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AP003551, BC010640, U26424
    Consensus CDS
    CCDS47900.1
    UniProtKB/Swiss-Prot
    A8K722, B3KYA7, Q13188, Q15445, Q15801, Q96FM6
    UniProtKB/TrEMBL
    A0A384MR07
    Related
    ENSP00000390500.2, ENST00000419617.7
    Conserved Domains (2) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    pfam11629
    Location:437484
    Mst1_SARAH; C terminal SARAH domain of Mst1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    98343975..98942610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422133.1XP_047278089.1  serine/threonine-protein kinase 3 isoform X6

  2. XM_017013756.2XP_016869245.1  serine/threonine-protein kinase 3 isoform X1

  3. XM_011517251.3XP_011515553.1  serine/threonine-protein kinase 3 isoform X4

    Conserved Domains (2) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:27278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. XM_047422132.1XP_047278088.1  serine/threonine-protein kinase 3 isoform X5

  5. XM_011517252.4XP_011515554.2  serine/threonine-protein kinase 3 isoform X7

  6. XM_011517248.3XP_011515550.2  serine/threonine-protein kinase 3 isoform X2

  7. XM_047422135.1XP_047278091.1  serine/threonine-protein kinase 3 isoform X11

  8. XM_017013761.3XP_016869250.1  serine/threonine-protein kinase 3 isoform X10

  9. XM_017013758.2XP_016869247.1  serine/threonine-protein kinase 3 isoform X8

  10. XM_047422134.1XP_047278090.1  serine/threonine-protein kinase 3 isoform X9

  11. XM_017013757.2XP_016869246.1  serine/threonine-protein kinase 3 isoform X3

  12. XM_011517257.3XP_011515559.2  serine/threonine-protein kinase 3 isoform X13

  13. XM_047422137.1XP_047278093.1  serine/threonine-protein kinase 3 isoform X14

  14. XM_047422136.1XP_047278092.1  serine/threonine-protein kinase 3 isoform X12

RNA

  1. XR_007060753.1 RNA Sequence

  2. XR_007060752.1 RNA Sequence

  3. XR_007060754.1 RNA Sequence

  4. XR_007060755.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    99469462..100069002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361076.1XP_054217051.1  serine/threonine-protein kinase 3 isoform X6

  2. XM_054361071.1XP_054217046.1  serine/threonine-protein kinase 3 isoform X1

  3. XM_054361074.1XP_054217049.1  serine/threonine-protein kinase 3 isoform X4

  4. XM_054361075.1XP_054217050.1  serine/threonine-protein kinase 3 isoform X5

  5. XM_054361077.1XP_054217052.1  serine/threonine-protein kinase 3 isoform X7

  6. XM_054361072.1XP_054217047.1  serine/threonine-protein kinase 3 isoform X2

  7. XM_054361080.1XP_054217055.1  serine/threonine-protein kinase 3 isoform X10

  8. XM_054361078.1XP_054217053.1  serine/threonine-protein kinase 3 isoform X8

  9. XM_054361079.1XP_054217054.1  serine/threonine-protein kinase 3 isoform X9

  10. XM_054361073.1XP_054217048.1  serine/threonine-protein kinase 3 isoform X3

  11. XM_054361082.1XP_054217057.1  serine/threonine-protein kinase 3 isoform X13

  12. XM_054361083.1XP_054217058.1  serine/threonine-protein kinase 3 isoform X14

  13. XM_054361081.1XP_054217056.1  serine/threonine-protein kinase 3 isoform X12

RNA

  1. XR_008487876.1 RNA Sequence

  2. XR_008487875.1 RNA Sequence

  3. XR_008487874.1 RNA Sequence

  4. XR_008487877.1 RNA Sequence