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Ppp6c protein phosphatase 6, catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 67857, updated on 2-Nov-2024

Summary

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Official Symbol
Ppp6cprovided by MGI
Official Full Name
protein phosphatase 6, catalytic subunitprovided by MGI
Primary source
MGI:MGI:1915107
See related
Ensembl:ENSMUSG00000026753 AllianceGenome:MGI:1915107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pp6C; 2310003C10Rik
Summary
Enables protein serine/threonine phosphatase activity. Predicted to be involved in G1/S transition of mitotic cell cycle and negative regulation of cGAS/STING signaling pathway. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in central nervous system; pancreas epithelium; and retina. Orthologous to human PPP6C (protein phosphatase 6 catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 11.6), bladder adult (RPKM 11.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp6c in Genome Data Viewer
Location:
2 B; 2 24.44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (39084381..39116361, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (39194369..39226349, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene suppressor of cancer cell invasion Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene mitochondrial ribosomal protein L40 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3372 Neighboring gene STARR-seq mESC enhancer starr_04346 Neighboring gene STARR-seq mESC enhancer starr_04347 Neighboring gene vomeronasal 2, receptor, pseudogene 2 Neighboring gene predicted gene, 57696

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis. Ogoh H, et al. Mech Dev, 2016 Feb. PMID 26868000
  2. Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma. Shen Y, et al. Cell Death Dis, 2011 Dec 8. PMID 22158480, Free PMC Article
  3. Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA. Hayashi K, et al. Oncogene, 2015 Aug 27. PMID 25486434
  4. PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features. Fukui K, et al. Cancer Sci, 2022 May. PMID 35247012, Free PMC Article
  5. Ppp6c deficiency accelerates K-ras(G12D) -induced tongue carcinogenesis. Kishimoto K, et al. Cancer Med, 2021 Jul. PMID 34145991, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Depletion of Ppp6c in hematopoietic and vascular endothelial cells causes embryonic lethality and decreased hematopoietic potential.
    Title: Depletion of Ppp6c in hematopoietic and vascular endothelial cells causes embryonic lethality and decreased hematopoietic potential.
  2. Oncogenic K-Ras[G12V] cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
    Title: Oncogenic K-Ras(G12V) cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
  3. Neuron-specific loss of Ppp6c induces neonatal death and decreases the number of cortical neurons and interneurons.
    Title: Neuron-specific loss of Ppp6c induces neonatal death and decreases the number of cortical neurons and interneurons.
  4. Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1.
    Title: Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1.
  5. PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.
    Title: PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.
  6. Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis.
    Title: Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis.
  7. Ppp6c deficiency accelerates K-ras(G12D) -induced tongue carcinogenesis.
    Title: Ppp6c deficiency accelerates K-ras(G12D) -induced tongue carcinogenesis.
  8. Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.
    Title: Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.
  9. Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
    Title: Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
  10. Ppp6c deficiency enhances K-ras(G12D) -dependent tumor promotion
    Title: Loss of protein phosphatase 6 in mouse keratinocytes enhances K-ras(G12D) -driven tumor promotion.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (6)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cGAS/STING signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cGAS/STING signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 6 catalytic subunit
NP_077171.1
XP_006498319.1
XP_017174716.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024209.3 → NP_077171.1  serine/threonine-protein phosphatase 6 catalytic subunit

    See identical proteins and their annotated locations for NP_077171.1

    Status: VALIDATED

    Source sequence(s)
    AK002764, AK009104, BE634938, BY197919, CD546325
    Consensus CDS
    CCDS16017.1
    UniProtKB/Swiss-Prot
    A2ASL7, Q9CQR6
    Related
    ENSMUSP00000028087.4, ENSMUST00000028087.6
    Conserved Domains (1) summary
    cd07415
    Location:5 → 289
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    39084381..39116361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498256.4 → XP_006498319.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_006498319.1

    Conserved Domains (1) summary
    cl13995
    Location:1 → 211
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  2. XM_017319227.3 → XP_017174716.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

    Conserved Domains (1) summary
    cl13995
    Location:45 → 207
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQR6.1 GenPept UniProtKB/Swiss-Prot:Q9CQR6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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