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PPP6C protein phosphatase 6 catalytic subunit [ Homo sapiens (human) ]

Gene ID: 5537, updated on 7-Jun-2020

Summary

Official Symbol
PPP6Cprovided by HGNC
Official Full Name
protein phosphatase 6 catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:9323
See related
Ensembl:ENSG00000119414 MIM:612725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP6; PP6C
Summary
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 20.0), fat (RPKM 18.6) and 25 other tissues See more
Orthologs

Genomic context

See PPP6C in Genome Data Viewer
Location:
9q33.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (125146573..125189939, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127908852..127952218, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene golgin A1 Neighboring gene RNA, U4 small nuclear 82, pseudogene Neighboring gene suppressor of cancer cell invasion Neighboring gene frataxin pseudogene 2 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene 2 Neighboring gene uncharacterized LOC105376271 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 2 Neighboring gene ribosomal protein SA pseudogene 76

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, protein phosphatase 6, catalytic subunit (PPP6C), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ92648, MGC12249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 6 catalytic subunit
Names
serine/threonine protein phosphatase catalytic subunit
NP_001116827.1
NP_001116841.1
NP_002712.1
XP_011517149.1
XP_024303375.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123355.1NP_001116827.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform a

    See identical proteins and their annotated locations for NP_001116827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript; it encodes the longest isoform (a).
    Source sequence(s)
    AA251321, AL445930, BC006990, CB250498, DB037210, DC334216
    Consensus CDS
    CCDS48018.1
    UniProtKB/Swiss-Prot
    O00743
    Related
    ENSP00000392147.1, ENST00000451402.5
    Conserved Domains (1) summary
    cd07415
    Location:5326
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  2. NM_001123369.1NP_001116841.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform c

    See identical proteins and their annotated locations for NP_001116841.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one coding exon compared to variant 1 and encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AA251321, AL445930, BC006990, CB250498, DB037210, DC307002, DC369815
    Consensus CDS
    CCDS48019.1
    UniProtKB/Swiss-Prot
    O00743
    Related
    ENSP00000411744.1, ENST00000415905.5
    Conserved Domains (1) summary
    cd07415
    Location:5267
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  3. NM_002721.5NP_002712.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform b

    See identical proteins and their annotated locations for NP_002712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the coding region, compared to variant 1; it encodes a shorter isoform (b).
    Source sequence(s)
    AA251321, AL445930, BC006990, CB250498, DB037210
    Consensus CDS
    CCDS6861.1
    UniProtKB/Swiss-Prot
    O00743
    UniProtKB/TrEMBL
    A0A024R861
    Related
    ENSP00000362648.4, ENST00000373547.8
    Conserved Domains (1) summary
    cd07415
    Location:5289
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    125146573..125189939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447607.1XP_024303375.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

    Conserved Domains (1) summary
    cl13995
    Location:2142
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  2. XM_011518847.3XP_011517149.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X1

    Conserved Domains (2) summary
    PTZ00239
    Location:15293
    PTZ00239; serine/threonine protein phosphatase 2A; Provisional
    cd07415
    Location:13277
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
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