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Brix1 BRX1, biogenesis of ribosomes [ Mus musculus (house mouse) ]

Gene ID: 67832, updated on 12-May-2024


Official Symbol
Brix1provided by MGI
Official Full Name
BRX1, biogenesis of ribosomesprovided by MGI
Primary source
See related
Ensembl:ENSMUSG00000022247 AllianceGenome:MGI:1915082
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bxdc2; 1110064N10Rik
Predicted to enable RNA binding activity. Predicted to be involved in ribosomal large subunit assembly. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human BRIX1 (biogenesis of ribosomes BRX1). [provided by Alliance of Genome Resources, Apr 2022]
Broad expression in CNS E11.5 (RPKM 13.6), liver E14 (RPKM 10.4) and 17 other tissues See more
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Genomic context

See Brix1 in Genome Data Viewer
15 A1; 15 5.35 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10474865..10486023, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10474779..10485937, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52213 Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene STARR-positive B cell enhancer ABC_E9414 Neighboring gene STARR-seq mESC enhancer starr_37954 Neighboring gene RAD1 checkpoint DNA exonuclease Neighboring gene tetratricopeptide repeat domain 23-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
located_in nucleus IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
ribosome biogenesis protein BRX1 homolog
BRX1, biogenesis of ribosomes, homolog
brix domain containing 2
brix domain-containing protein 2
ribosome biogenesis protein Brix

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026396.3NP_080672.3  ribosome biogenesis protein BRX1 homolog

    See identical proteins and their annotated locations for NP_080672.3

    Status: VALIDATED

    Source sequence(s)
    AK002985, AK010171, CF749026, DT927497
    Consensus CDS
    Q3THD3, Q91YS6, Q9DCA5
    ENSMUSP00000022855.6, ENSMUST00000022855.12
    Conserved Domains (1) summary
    Brix; Brix domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000081.7 Reference GRCm39 C57BL/6J

    10474865..10486023 complement
    GenBank, FASTA, Sequence Viewer (Graphics)