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Brix1 BRX1, biogenesis of ribosomes [ Mus musculus (house mouse) ]

Gene ID: 67832, updated on 26-Sep-2022

Summary

Official Symbol
Brix1provided by MGI
Official Full Name
BRX1, biogenesis of ribosomesprovided by MGI
Primary source
MGI:MGI:1915082
See related
Ensembl:ENSMUSG00000022247 AllianceGenome:MGI:1915082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bxdc2; 1110064N10Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in ribosomal large subunit assembly. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human BRIX1 (biogenesis of ribosomes BRX1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 13.6), liver E14 (RPKM 10.4) and 17 other tissues See more
Orthologs
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Genomic context

See Brix1 in Genome Data Viewer
Location:
15; 15 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10474865..10486023, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10474779..10485937, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52213 Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene RAD1 checkpoint DNA exonuclease Neighboring gene tetratricopeptide repeat domain 23-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribosome biogenesis protein BRX1 homolog
Names
BRX1, biogenesis of ribosomes, homolog
brix domain containing 2
brix domain-containing protein 2
ribosome biogenesis protein Brix

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026396.3NP_080672.3  ribosome biogenesis protein BRX1 homolog

    See identical proteins and their annotated locations for NP_080672.3

    Status: VALIDATED

    Source sequence(s)
    AK002985, AK010171, CF749026, DT927497
    Consensus CDS
    CCDS37042.1
    UniProtKB/Swiss-Prot
    Q91YS6, Q9DCA5
    UniProtKB/TrEMBL
    Q8CEX3
    Related
    ENSMUSP00000022855.6, ENSMUST00000022855.12
    Conserved Domains (1) summary
    cl00935
    Location:36307
    Brix; Brix domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    10474865..10486023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)