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BRIX1 biogenesis of ribosomes BRX1 [ Homo sapiens (human) ]

Gene ID: 55299, updated on 17-Jun-2019

Summary

Official Symbol
BRIX1provided by HGNC
Official Full Name
biogenesis of ribosomes BRX1provided by HGNC
Primary source
HGNC:HGNC:24170
See related
Ensembl:ENSG00000113460 MIM:618466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRIX; BXDC2
Expression
Ubiquitous expression in placenta (RPKM 18.1), bone marrow (RPKM 18.1) and 25 other tissues See more
Orthologs

Genomic context

See BRIX1 in Genome Data Viewer
Location:
5p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (34915711..34925996)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (34915820..34925787)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 23 like Neighboring gene ribosomal protein L21 pseudogene 54 Neighboring gene RAD1 checkpoint DNA exonuclease Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene alanine--glyoxylate aminotransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gastric Cancer Network 2, organism-specific biosystem (from WikiPathways)
    Gastric Cancer Network 2, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Network generated by Ingenuity Pathway Analysis.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11100

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ribosome biogenesis protein BRX1 homolog
Names
BRX1, biogenesis of ribosomes, homolog
brix domain containing 2
brix domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018321.4NP_060791.3  ribosome biogenesis protein BRX1 homolog

    See identical proteins and their annotated locations for NP_060791.3

    Status: VALIDATED

    Source sequence(s)
    AC026801, BC001546
    Consensus CDS
    CCDS34143.1
    UniProtKB/Swiss-Prot
    Q8TDN6
    Related
    ENSP00000338862.5, ENST00000336767.5
    Conserved Domains (2) summary
    pfam09785
    Location:321346
    Prp31_C; Prp31 C terminal domain
    cl00935
    Location:58307
    Brix; Brix domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    34915711..34925996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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