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STC1 stanniocalcin 1 [ Homo sapiens (human) ]

Gene ID: 6781, updated on 1-Jun-2020

Summary

Official Symbol
STC1provided by HGNC
Official Full Name
stanniocalcin 1provided by HGNC
Primary source
HGNC:HGNC:11373
See related
Ensembl:ENSG00000159167 MIM:601185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STC
Summary
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 33.6), thyroid (RPKM 19.7) and 14 other tissues See more
Orthologs

Genomic context

See STC1 in Genome Data Viewer
Location:
8p21.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (23841929..23854806, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (23699434..23712320, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986930 Neighboring gene uncharacterized LOC101929258 Neighboring gene Sharpr-MPRA regulatory region 6499 Neighboring gene uncharacterized LOC107986931 Neighboring gene Sharpr-MPRA regulatory region 10080 Neighboring gene RNA, U1 small nuclear 148, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
New loci associated with kidney function and chronic kidney disease.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bone development IDA
Inferred from Direct Assay
more info
PubMed 
cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucocorticoid stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
chondrocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
decidualization IEA
Inferred from Electronic Annotation
more info
 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
endothelial cell morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
growth plate cartilage axis specification IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of renal phosphate excretion IDA
Inferred from Direct Assay
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion import IDA
Inferred from Direct Assay
more info
PubMed 
regulation of anion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac muscle cell contraction IDA
Inferred from Direct Assay
more info
PubMed 
response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029711.1 RefSeqGene

    Range
    5002..17879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003155.3NP_003146.1  stanniocalcin-1 precursor

    See identical proteins and their annotated locations for NP_003146.1

    Status: REVIEWED

    Source sequence(s)
    AC012119, BC029044, U25997
    Consensus CDS
    CCDS6043.1
    UniProtKB/Swiss-Prot
    P52823
    Related
    ENSP00000290271.2, ENST00000290271.7
    Conserved Domains (1) summary
    pfam03298
    Location:6206
    Stanniocalcin; Stanniocalcin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    23841929..23854806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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