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Rmdn3 regulator of microtubule dynamics 3 [ Mus musculus (house mouse) ]

Gene ID: 67809, updated on 27-Feb-2024

Summary

Official Symbol
Rmdn3provided by MGI
Official Full Name
regulator of microtubule dynamics 3provided by MGI
Primary source
MGI:MGI:1915059
See related
Ensembl:ENSMUSG00000070730 AllianceGenome:MGI:1915059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rmd3; RMD-3; Fam82a2; Ptpip51; 1200015F23Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in cellular calcium ion homeostasis. Predicted to act upstream of or within apoptotic process and cell differentiation. Located in mitochondrion. Is expressed in several structures, including eye. Orthologous to human RMDN3 (regulator of microtubule dynamics 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 12.0), placenta adult (RPKM 9.8) and 28 other tissues See more
Orthologs
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Genomic context

See Rmdn3 in Genome Data Viewer
Location:
2 E5; 2 59.94 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118967479..118987515, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119136998..119157034, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene kinetochore scaffold 1 Neighboring gene RAD51 recombinase Neighboring gene STARR-positive B cell enhancer ABC_E7851 Neighboring gene GTP cyclohydrolase I feedback regulator Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 Neighboring gene predicted gene 14137

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitotic spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in organelle membrane contact site ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
regulator of microtubule dynamics protein 3
Names
family with sequence similarity 82, member A2
microtubule-associated protein
protein tyrosine phosphatase-interacting protein 51
tyrosine phosphatase interacting protein 51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033136.3NP_001028308.1  regulator of microtubule dynamics protein 3

    See identical proteins and their annotated locations for NP_001028308.1

    Status: VALIDATED

    Source sequence(s)
    AK151090, AL772264, BY453591
    Consensus CDS
    CCDS16591.1
    UniProtKB/Swiss-Prot
    A9UN03, Q3U5Y8, Q3UB61, Q3UJU9, Q6P8M2, Q7TNF2
    Related
    ENSMUSP00000092283.6, ENSMUST00000094695.12
    Conserved Domains (1) summary
    sd00006
    Location:363413
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    118967479..118987515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_374514.1 RNA Sequence

  2. XR_004940711.1 RNA Sequence