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Tprg1l transformation related protein 63 regulated 1 like [ Mus musculus (house mouse) ]

Gene ID: 67808, updated on 2-Nov-2024

Summary

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Official Symbol
Tprg1lprovided by MGI
Official Full Name
transformation related protein 63 regulated 1 likeprovided by MGI
Primary source
MGI:MGI:1915058
See related
Ensembl:ENSMUSG00000029030 AllianceGenome:MGI:1915058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tprgl; mover; Svap30; 1200015A19Rik
Summary
Enables calmodulin binding activity and identical protein binding activity. Acts upstream of or within calcineurin-NFAT signaling cascade; negative regulation of synaptic transmission; and synaptic vesicle docking. Located in presynapse. Is expressed in several structures, including gut; hemolymphoid system gland; male reproductive gland or organ; nervous system; and nose. Orthologous to human TPRG1L (tumor protein p63 regulated 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 110.0), lung adult (RPKM 103.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tprg1l in Genome Data Viewer
Location:
4 E2; 4 83.88 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154241942..154246763, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154157485..154162306, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transformation related protein 73 Neighboring gene STARR-positive B cell enhancer ABC_E4737 Neighboring gene predicted gene, 26036 Neighboring gene STARR-positive B cell enhancer ABC_E1045 Neighboring gene WD repeat containing, antisense to Trp73 Neighboring gene STARR-seq mESC enhancer starr_12229 Neighboring gene multiple EGF-like-domains 6 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene Rho guanine nucleotide exchange factor 16 Neighboring gene predicted gene, 52687

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of a subset of release-ready vesicles by the presynaptic protein Mover. Pofantis E, et al. Proc Natl Acad Sci U S A, 2021 Jan 19. PMID 33431696, Free PMC Article
  2. Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis. Burré J, et al. Electrophoresis, 2006 Sep. PMID 16944461
  3. Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques. Burré J, et al. Proteomics, 2006 Dec. PMID 17080482
  4. Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses. Kremer T, et al. FEBS Lett, 2007 Oct 2. PMID 17869247
  5. The Calmodulin Binding Region of the Synaptic Vesicle Protein Mover Is Required for Homomeric Interaction and Presynaptic Targeting. Akula AK, et al. Front Mol Neurosci, 2019. PMID 31787876, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of a subset of release-ready vesicles by the presynaptic protein Mover.
    Title: Regulation of a subset of release-ready vesicles by the presynaptic protein Mover.
  2. Tprgl is a ubiquitously expressed gene located upstream of the p73 gene. Its encoded protein displays 44% amino acid identity with the protein encoded by Tprg, a p63 target gene that is located upstream of the p63 gene.
    Title: Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63.
  3. mover may act in concert with generally expressed scaffolding proteins in distinct sets of presynaptic terminals
    Title: Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within synaptic vesicle docking IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
  
located_in calyx of Held ISO
Inferred from Sequence Orthology
more info
  
located_in calyx of Held ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extrinsic component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor protein p63-regulated gene 1-like protein
Names
mossy-fiber terminal-associated vertebrate-specific presynaptic protein
synaptic vesicle associated protein of 30 kD
transformation related protein 63 regulated like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026388.2 → NP_080664.1  tumor protein p63-regulated gene 1-like protein

    See identical proteins and their annotated locations for NP_080664.1

    Status: VALIDATED

    Source sequence(s)
    AI840915, AK004324, AK004777, BY739996
    Consensus CDS
    CCDS19011.1
    UniProtKB/Swiss-Prot
    B1AX99, Q8BTC6, Q9DBS2
    Related
    ENSMUSP00000030896.9, ENSMUST00000030896.15
    Conserved Domains (1) summary
    pfam12456
    Location:61 → 162
    hSac2; Inositol phosphatase

RNA

  1. NR_151647.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI840915, AK004324, AK004777, AL806525, BY739996

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    154241942..154246763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539129.4 → XP_006539192.3  tumor protein p63-regulated gene 1-like protein isoform X1

    Conserved Domains (2) summary
    pfam12456
    Location:174 → 264
    hSac2; Inositol phosphatase
    cl02324
    Location:93 → 197
    DUF721; Protein of unknown function (DUF721)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBS2.1 GenPept UniProtKB/Swiss-Prot:Q9DBS2

Gene LinkOut

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